Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Translational Medicine and Chemical Biology

Division
For our growing interdisciplinary and multi-national team, we are looking for a highly skilled and motivated coworkers.    Histone proteins provide a dynamic packaging system for the eukaryotic genome. Chromatin integrates a multitude of signals to control gene expression, only some of which have the propensity to be maintained through replication and cell division. To unravel the molecular circuits that underlie epigenetic gene regulation and inheritance, my laboratory aims to develops methods methods for studying and manipulating chromatin in living cells with high spatiotemporal resolution and biochemical precision. In an interdisciplinary team, we will combine chemical and synthetic biology manipulation of living cells with systems-level (genomic and proteomic) readouts. For more information and latest news visit http://elsaesserlab.org.

Duties
We are recruiting a postdoctoral fellow for the ERC-funded project "RAPID", which aims to elucidate chromatin dynamics with high-resolution, quantitative genomics methods, at the scale of minutes to days. Tasks will include:

  • purifying sub populations of cells e.g. by cell cycle using flow sorting or alternative methods
  • performing and optimising quantitative ChIP-Seq experiments
  • ChIP-Seq library preparation and Illumina sequencing
  • data analysis through a bioinformatics pipeline

Requirements
Excellent education and previous experience in molecular biology, biochemistry, chromatin biology, genomics is a prerequisite. The ideal candidates have will have the following skills to perform the tasks above:

1) A PhD thesis in the field of developmental, cell or molecular biology

2) extensive experience in biochemistry, molecular biology and chromatin-specific methodologies such as ChIP-Seq

3)extensive experience in cellular or organismal model systems, such as mouse embryonic stem cells

4)robust mathematical and statistical background knowledge

The candidate should be enthusiastic, motivated, result-driven, and creative minded, with good organization, writing and communication skills. The candidate should be interested in fundamental research questions and be able to work well both independently and in a team environment.

Application process

Applications should include full CV including grades of degrees, motivation letter stating the reasons for being interested in my lab and three referees.

The application is to be submitted through the Varbi recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-5274/2018
Contact
  • Simon Elssäser , +46 8 524 800 00 / simon.elsasser@ki.se
Union representative
  • Anne Edgren, OFR/S, P, O, 08-524 87570
  • Biborka Bereczky Veress, SACO, 46 70-173 85 75 , biborka.bveress@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
Published 02.Oct.2018
Last application date 12.Oct.2018 11:59 PM CET

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