Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism

Division
The Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, is located at the newly built and modern laboratory Biomedicum at Solna campus of Karolinska Institutet. The research at the Division of Molecular Metabolism aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease and ageing. The current research encompasses biochemical and genetic studies of patients with inherited diseases as well as basic scientific approaches to understand the regulation of mitochondrial metabolism. Both patient material (tissues and cells) and genetically modified fruit flies (Drosophila melanogaster) and mice (Mus musculus) are used in these studies. The overall aim of the Division of Molecular Metabolism is to combine these different areas of research to get insights into disease pathophysiology and to develop novel treatments.
The Division of Molecular Metabolism offers an outstanding research environment and a close interaction between basic science and clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. The newly founded Max Planck Institute for Biology of Ageing - Karolinska Institutet Laboratory (MPI-KI laboratory) is also integrated into our laboratory. Excellent access to the most advanced resources in molecular and cell biology is available at the department and at the national core facilities at the Science for Life Laboratory.

We are currently looking for 1-2 highly motivated postdoctoral researchers, to join the research group of Nils-Göran Larsson.

Duties
Studies of the regulation of mitochondrial function with special focus on gene expression, the role of mitochondrial DNA (mtDNA) mutations in disease and ageing, and fundamental principles for maternal transmission of mtDNA. Mitochondria are essential for cell function and mitochondrial dysfunction has been implicated in a variety of hereditary diseases, age-related diseases and the normal ageing process. Using mouse models, biochemistry, molecular biology and modern -omics approaches, the group of Nils-Göran Larsson focuses on understanding molecular processes determining how mitochondrial dysfunction causes disease and ageing.

Entry requirements
Applications are invited from enthusiastic and motivated individuals with a PhD in molecular biology and mouse genetics. Experience in mitochondrial research is not required, whereas experience in biochemistry, molecular biology, mouse genetics and different -omics methods is of advantage.  Good documentation skills as well as proficiency in both spoken and written English are required. The successful candidates should be able and willing to work in a team to pursue his/her research. Personal suitability is of great importance when evaluating the applicants.

A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc.

Application process
An employment application must contain the following documents in English:

  • Curriculum vitae (max 2 pages)
  • List of publications
  • Personal motivation letter, explaining your research interests (max 1 page)
  • Contact information of at least two references

The application is to be submitted through the Varbi recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-4880/2018
Contact
  • Camilla Koolmeister, , Camilla.Koolmeister@ki.se / +46 8 524 800 00
Published 11.Sep.2018
Last application date 07.Oct.2018 11:59 PM CET

Tillbaka till lediga jobb