Karolinska Institutet, The Department of Medicine, Huddinge

Integrated Cardio Metabolic Centre (ICMC)
ICMC is a research collaboration between Karolinska Institutet and AstraZeneca.

The goal of the centre is to identify and validate new target molecules within the cardiovascular area and metabolic diseases. Special focus is placed on the stratrategic research areas: Cardiac Regeneration, Islet Health (Diabetes) and Diabetic Nephropathy.

This position offers direct collaborations with the Pharma Industry (i.e. AstraZeneca).

The successful applicant will work on single cell RNA sequencing including its translational aspects. The work will focus on different types of biomechanical stress in vitro and in vivo and its effect on cardiac myocyte survival. This project includes work with genetically altered animals, stem cell biology, explanted human hearts, CRISPR and next generation sequencing technologies, including RNA and single cell RNA seq, with the aim to identify molecular / epigenetic mechanisms underlying heart failure and its translation into innovative medications.

We are looking for a researcher who has a strong work ethic, passion for solving difficult questions & challenges with the ability to design, plan, perform, and interpret original experiments in an independent and innovative environment. The candidates should have high integrity and be aware of the multicultural setting they are going to be located at.

Candidates should

  • It is essential that the candidate has published at least one paper in an excellent peer-reviewed journal, preferably as a first author.
  • Have experience in basic science, preferably in single cell RNA seq / epigenetics and the generation of genetically altered animals. Experience in stem cell biology and administration is an additional merit.
  • Have a strong background in cardiac myocyte biology. Experiences in cell death pathways is an asset but not mandatory.
  • Knowledge in zebrafish genetics is an add on
  • Good experience in supervision of PhD students and master students is an asset but not mandatory.
  • Have the ability to work both independently and collaboratively in a group 

Necessary entry requirements
A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD in Medical/Biomedical sciences.

The candidate shall have extensive experiences in single cell RNA sequencing and the analysis of epigenetic events such as genomic DNA methylation, sequencing, CRISPR, animal models as well as cardiovascular related cell culture (both primary culture and cell lines), basic molecular biology and biochemistry.

Skills and personal qualities
You are thorough, diligent and used to documenting and organizing your work. You work in a clean and precise way. We expect you to be a positive, flexible person with good communication skills who appreciates being in a highly dynamic international research team. Due to the progressive nature of a scientific project we expect you to be comfortable with learning new methods. You can work independently after training but are still a team player and very service minded. Strong organizational skills as well as the ability to adapt quickly to changing priorities, assignments, and roles will be critical.

Furthermore, you have excellent communication skills in English in both writing and speaking.
Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. A Personal letter

The application is to be submitted through the Varbi recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-4665/2018
  • Ralph Knöll, ralph.knoell@ki.se
Union representative
  • Yvonne Edlund OFR/ST , yvonne.edlund@ki.se
  • Mats Rudling, SACO, mats.rudling@ki.se
Published 31.Aug.2018
Last application date 21.Sep.2018 11:59 PM CET

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