Karolinska Institutet,

At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

Division
Research at the Molecular & Cellular Exercise Physiology group is aimed at understanding the molecular mechanisms that mediate local and systemic adaptations to physical exercise. We are particularly interested in understanding how exercised or sedentary skeletal muscle can crosstalk with other organs, and how it can affect individual health and disease. To this end, we use in vitro and in vivo systems to dissect the regulatory mechanisms that are activated by exercise and that control the different exercise-induced adaptations. By better understanding the signal transduction and gene regulatory pathways that control local and systemic adaptations to physical exercise, we aim at developing future therapeutic strategies for the treatment of metabolic and degenerative diseases such as diabetes, obesity, sarcopenia and neuromuscular disorders. More information about our research group can be found at www.ki.se/research/jorgeruas

Duties
We are looking for a highly motivated co-worker with a PhD degree in an area relevant for this position. The project to be developed aims at characterizing the role of a novel protein we have identified to play a role in liver and skeletal muscle disease. The successful applicant will be responsible for the characterization of newly established tissue-specific knockout mouse lines in terms of metabolism (e.g. CLAMS) and tissue response to injury. The candidate will also generate diverse recombinant viral vectors and use them for gain- and loss-of-function experiments, both in vivo and in primary myotube and hepatocyte cultures. The candidate is expected to be heavily involved in project design, implementation, analysis, and interpretation, in close collaboration with other team members. The candidate is also expected to communicate scientific findings in conferences and articles published in peer-reviewed journals.

Entry requirements
A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc.

Other requirements
The candidate should have experience in tissue culture techniques including the isolation, preparation, and maintenance of mouse primary myoblasts and hepatocytes. Additionally, the candidate should have experience with handling and manipulation of laboratory animals, and a strong background in animal physiology and molecular biology. The candidate should also be experienced in techniques necessary for the execution of the project, such as DNA cloning, quantitative real-time PCR, and generation and utilization of adeno and adeno-associated viruses. Having FELASA C certification and experience with bioinformatic analysis of gene expression data are merits.
Very good communication skills and an ability to interact socially and scientifically with other post docs and students in the laboratory and with collaborators in various networks are essential. A good command of the english language is needed for this position. The ideal candidate should be ambitious and strongly motivated to develop the proposed project.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100 %
City Solna
County Stockholms län
Country Sweden
Reference number 2-4193/2018
Contact
  • Jorge Ruas, Group leader, Jorge.ruas@ki.se
Union representative
  • Bo Rydqvist, SACO, 08-524 872 67, bo.rydqvist@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
  • Niklas Andersson, OFR, niklas.andersson@ki.se
Published 06.Sep.2018
Last application date 19.Sep.2018 11:59 PM CET

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