Karolinska Institutet, Dept. of Oncology-pathology, Research group Lehtiö

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. About 30 research groups with various cancer research profiles are involved and we have around 110 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

SciLifeLab/Clinical Proteomics Mass Spectrometry
The position is within the core facility for Clinical Proteomics Mass Spectrometry led by Professor Janne Lehtiö, located at the Science for Life Laboratory in Solna. The core facility is tasked with aiding users of Swedish universities and industries with proteomics projects. The facility offers a unique research infrastructure and expertise with focus on mass spectrometry (MS) based proteomics. Our robust, highly sensitive techniques allow us to identify and quantify thousands of different proteins within a single sample.
The Clinical Proteomics Mass Spectrometry platform is equipped with the latest peptide separation techniques and MS instrumentation including a suite of mass spectrometers with complementary characteristics. The instrument platform consists of a plurality of high-resolution LC-MS instruments for proteomics and post-translational modification analysis and triple quadrupole instrument for targeted MS analysis. The MS-platform facility provides fee-for-service sample analysis as well as support to plan and perform larger in depth proteomics projects.
The core facility works in close collaboration with Prof. Janne Lehtiö’s research group, where MS based proteomics methods are constantly developed and applied to studies aiming at improving individual cancer therapy. This collaboration is a prerequisite for the core facility’s ability to offer services at the forefront of MS based proteomics.

We are looking for a research engineer or equivalent for our Clinical Proteomics Mass Spectrometry core facility. The position is for one year.

Job description/duties
The responsibilities accompanying this position include sample preparation, bio analytical work, analysis and reporting of protein/peptide expression, method development, and coordination of core facility projects. A major aspect of this position involves laboratory work, thus experience in a laboratory is essential. Work will be performed together with the mass spectrometry team in the core facility.
The research engineer will be part of a research infrastructure, working closely with project scientists, postdoctoral fellows, PhD-students, undergraduate students, and external users/customers within academia and industry. Important aspects of the job include:

  • Preparation of in vivo and in vitro samples
  • Experimental analysis of samples by mass spectrometry
  • Compiling and analyzing proteomics data
  • Data management and data services
  • Tracking projects status and continuous contact with customers by email/phone

The work involves a combination of flexible and routine tasks and places a great emphasis on independence, initiative, precision, and planning. The position involves a variety of tasks in a stimulating research environment. Nice and helpful colleagues contribute to a good working environment within the group.
A large part of the job may be contact with customers/researchers from a wide range of fields, which is an exciting, interesting and instructive part of the work. The group sits in the newly constructed Science for Life Laboratory with spacious and modern facilities.

The successful candidate should have:


  • BSc or MSc degree in analytical chemistry, biochemistry, biotechnology or in a related field
  • Extensive hands on experience in the laboratory and ability to follow SOPs in daily work
  • Competence/experience in MS-based clinical proteomics research
  • Experience in core facility work
  • Excellent communication and organizational skills
  • Good knowledge (both speaking and writing) of English


  • Experience in MS as an analytical method
  • Hands-on experience with LC and MS instruments
  • Understanding of analytical chemistry
  • Ability to analyze proteomics data
  • Experience of purchasing and procurement
  • Strong interests of working in centralized shared research infrastructures

We place great emphasis on personal suitability. To succeed in the role, it is important that the applicant is development oriented and has personal drive and patience. The applicant should be responsible, have a great sense of service, appreciate daily, detailed work as well as have the ability to see the big picture. The applicant should be an effective communicator, have good organizational skills, and be able to prioritize at times when the workload is high. The applicant should be able to collaborate with people of different backgrounds and at different levels (both within the group and with users from various disciplines).

Application process
The application is to be submitted through the Varbi recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
City Solna
County Stockholms län
Country Sweden
Reference number 2-3948/2018
  • Helena Bäckvall, 08 524 812 09, Helena.backvall@ki.se
Union representative
  • Mimmi Shoshan, SACO, 08 517 754 60
  • Helen Eriksson, OFR, 08 517 762 79
  • Andreas Lundqvist, SACO, 08 517 768 84, andreas.lundqvist@ki.se
Published 04.Jul.2018
Last application date 13.Jul.2018 11:59 PM CET

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