Karolinska Institutet

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 100 PhD students, 50 postdoctoral researchers and 26 professors. Key words are multidisciplinary, translational, national and international collaborations.

Division
The research group of Dr. Claudia Kutter seeks applications for a senior research specialist position in the field of RNA biology and genomics. The Kutter lab explores the molecular mechanism by which noncoding RNAs (i.e. long noncoding, transfer and small RNA) regulate genes and genome structure in somatic tissue and in the germline in mammals (Ernst et al. NatComm 2017, Rudolph et al. PLoS Genetics 2016, Schmitt et al. Genome Research 2014; Kutter et al. PLoS Genetics 2012; Kutter et al. Nature Genetics 2011).

The research program for this position focuses on the regulation of noncoding RNAs during cell differentiation and disease progression, with a particular interest in the involvement of RNA binding proteins during transcript processing and how they synergize with other cofactors in mammalian systems by using diverse cell lines, mouse and human tissues as model system. The roles of noncoding RNAs are interrogated genome- and transcriptome-wide by employing a combination of next generation sequencing technologies and high-throughput genetic screening approaches, development of computational methods, along with additional biochemical, molecular and cell biological methods. The group uses an integrative and collaborative approach, and works closely with experimental and computational groups at the MTC, Science for Life Laboratory (SciLifeLab), and other local and international research groups.

The laboratory is located in the newly established SciLifeLab on the Karolinska Institute campus in Stockholm. The SciLifeLab offers an attractive research environment, provides state-of-the-art instrumentation and core facilities, and is home to the second largest sequencing cluster in Europe. The SciLifeLab is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology (KTH), and Stockholm University. It hosts research groups with diverse backgrounds and expertise, creating a unique interface between basic biology, genomics, bioengineering, drug discovery, and translational medicine.

We are looking for a highly motivated person with strong competence in both experimental (genomic data generation) and computational (data analysis, visualization and interpretation) approaches.

Duties
The successful applicant will apply and optimize novel transcriptome- and genome-wide approaches (such as RNA-sequencing and epigenome profiling techniques) to study the processing and regulation of noncoding RNAs in cultured cells and primary tissue of human and mouse, and carry out validation experiments involving biochemical and molecular biological tools. Additionally, the candidate will integrate transcriptome- and genome-wide computational methods (based on RNA- and ChIP-sequencing data) to study the processing and regulation of noncoding RNAs in mammalian cell lines.

The post holder will take a strong lead in the project design and management as well as data generation, analyses and interpretation. The candidate will also be in charge of the group’s sequencer, guide other team members and work together with our collaborators. The ideal candidate is expected to report the scientific results by writing scientific papers, attending scientific meetings, effectively communicate with peers and participate in the general duties of the team. The ability to work in a highly interdisciplinary and international environment and to engage in continuous professional development is a must.

Qualifications
A strong background in genomics, molecular biology, genetics, and experience in high-throughput biological data analysis and computational biology is required. Applicants to this position must have a PhD in genomics, computational biology, cellular or molecular biology. Research experience from abroad is an advantage. Proven experiences in eukaryotic RNA biology, gene regulation, transcriptome-wide studies, epigenetics, mammalian tissue culture techniques, CRISPR/Cas technology, bioinformatics and R programming for statistical computing and graphics are required. The ideal candidate should be collaborative, scientifically adventurous, curiosity-driven, and should bring independent and original ideas into the project. Any previous records of independent research as well as productive interactions within a multi-disciplinary team environment (e.g. several first- and/or co-author publications) are beneficial. All applicants should have good communication skills and be proficient in spoken and written English.

For more information on the work of the laboratory, please visit: https://ki.se/en/mtc/claudia-kutter-group

Application process
An application must contain the following documents in English:

  1. Letter of motivation and a summary of current work (about one page)
  2. Curriculum vitae and qualifications
  3. Complete publication list
  4. Contact information of three referees
  5. Copy of degree certificates
  6. If available, verifications for crediting of illness, military service, work for labor unions or student organizations, parental leave or similar circumstances

 The application is to be submitted on the Varbi/MyNetwork recruitment system.

At Karolinska Institutet a 6-month trial period is required for all permanent appointments.

Type of employment Tillsvidareanställning
Contract type Full time
City Solna
County Stockholms län
Country Sweden
Reference number 2-3198/2018
Contact
  • Claudia Kutter, Assistant Professor, claudia.kutter@ki.se
Union representative
  • Daisy Hjelmqvist SACO, daisy.hjelmqvist@ki.se
  • Niklas Andersson, OFR, niklas.andersson@ki.se
Published 05.Jun.2018
Last application date 14.Jun.2018 11:59 PM CET

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