Karolinska Institutet, Institutionen för Medicinsk biokemi och biofysik, Translational Medicine and Chemical Biology

A part-time postdoctoral position is immediately available in the Crosetto Laboratory (https://bienkocrosettolabs.org/) with the goal of studying genetic heterogeneity in lung cancer and corresponding brain metastases. The position is funded by a grant from the Swedish Foundation for Strategic Research awarded to Dr Crosetto to develop novel approaches for integrated visualization of intra-tumor heterogeneity.

Division
The Crosetto laboratory is located at SciLifeLab Stockholm (www.scilifelab.se), an interdisciplinary center for life sciences featuring state-of-the-art facilities and a broad range of groups working at the interface between biology, medicine, and computational sciences.

Duties
The successful candidate will have to carry out the following tasks:

  • DNA extraction and library preparation from large sample cohorts obtained in the frame of international collaborations
  • Exome capture
  • NGS on NextSeq 500
  • NGS data analysis (CNVs, mutations, fusions, etc.)
  • Tissue scanning and image analysis to identify different cell types using deep learning methods
  • Development of custom capture probes to assess mutations in selected fragile regions of the genome identified by the method BLISS developed in the Crosetto lab (Yan et al, Nat Commun 2017)

Entry requirements

  • PhD in medical science obtained no more than five years before the application deadline
  • Demonstrated prior expertise with mutation analysis and NGS in lung cancer
  • Demonstrated prior experience with molecular methods, optimization, and troubleshooting
  • Experience of working in clinical environment (prior work on lung cancer, pulmonology or diagnostic laboratory)
  • Experience in managing of research projects
  • Scientific experience in the field of lung cancer documented by publications and communications at international conferences
  • A strong motivation to work in a highly interdisciplinary and collaborative environment, and willingness to interact with scientists with computational background

 Application process

An employment application must contain the following documents in English:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position
  • A complete list of publications and communications on international conferences
  • A summary of current work (no more than one page)
  • Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances (only if applicable)
  • Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

The application is to be submitted through the Varbi recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Part-time
Number of positions 1
Working hours 40 %
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-2536/2018
Contact
  • Nicola Crosetto, +46 (0)73 986 53 79
Union representative
  • Anne Edgren, OFR/S, P, O, +46 (0)8-616 16 29
  • Biborka Bereczky Veress, SACO, +46 (0)70-173 85 75
  • Henry Wölling, SEKO, +46 (0)8-524 800 00
Published 02.May.2018
Last application date 16.May.2018 11:59 PM CET

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