Karolinska Institutet, Department of Oncology-Pathology, Research group Wiman

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. About 30 research groups with various cancer research profiles are involved and we have around 110 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

Research group
The group is led by professor Klas Wiman. Ongoing research in the group is focused on the tumor suppressor gene TP53 and development of novel cancer therapy. Wiman and colleagues have previously identified the compound APR-246 that reactivates missense mutant p53 and triggers tumor cell death. APR-246 is currently tested in a phase II clinical trial.

Project description
A significant fraction (10%) of TP53 mutations in human tumors are nonsense mutations that give rise to premature termination and expression of truncated non-functional p53 protein. In a new project funded by an Advanced ERC grant, Wiman and colleagues are identifying and developing novel compounds that can reactivate nonsense mutant TP53 by induction of translational readthrough of premature termination codons in TP53. The long term aim is clinical trials with one or several promising compounds and ultimately the development of novel anticancer drugs. An important part of this project is testing of candidate readthrough-inducing compounds in vivo in relevant mouse models. The successfulcandidate will be responsible for developing such mouse models, including nonsense mutant TP53 knock-in mice, to explore the ability of various compounds to induce readthrough and inhibit tumor growth in vivo. The project may open avenues for more efficient treatment of tumors that carry nonsense mutations in TP53 or other tumor suppressor genes, such as RB1, PTEN and APC.
The expected time for the project is 3 years.

We are looking for an ambitious, highly motivated and independent postdoctoral researcher with a solid background in molecular biology and/or tumor biology. The candidate should be well familiar with standard techniques such as cell culture, cell growth and cell death assays, PCR, Western, immunostaining and FACS. Previous experience with genetically modified mice and/or cancer drug discovery are strong merits.
This is a temporary position starting with 6 months, with good possibilities of prolongation for the rest of the project.

Entry requirements
A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.

Application process
An application must contain the following documents in English:

1) A complete curriculum vitae including the date of the thesis defense, title of the thesis, current position, academic awards and distinctions
2) A complete list of publications, with the top two publications clearly marked
3) A summary of previous and current work (one page, font 12)
4) Verifications for crediting of illness, military service, work for labor unions or student organizations, parental leave or similar (if relevant)
5) Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline)
6) Two letters of recommendation

The application is to be submitted through the Varbi recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-2104/2018
  • Klas Wiman, 08 517 793 42, klas.wiman@ki.se
Union representative
  • Andreas Lundqvist, SACO, 08 517 768 84, andreas.lundqvist@ki.se;
  • Helen Eriksson, OFR, 08 517 762 79
  • Mimmi Shoshan, SACO, 08 517 754 60
Published 08.Jun.2018
Last application date 01.Jul.2018 11:59 PM CET

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