Karolinska Institutet, Institutionen för medicin, Huddinge

We are looking for highly motivated and talented researchers to take the lead on high profile research projects through active pursuit of relevant experiments, and through regular interactions with the group leaders and important collaborators within and outside the research institute. Applicants are invited to submit applications for 10 available 1+1 year postdoctoral scholarships with an initial fixed term of one year. The positions are supported by prestigious grants from the Knut and Alice Wallenberg Foundation focused on basic and clinical studies on normal and malignant hematopoiesis. The research studies will be performed at the Center for Hematology and Regenerative Medicine (HERM; http://ki.se/en/medh/herm) and the research groups with available postdoc scholarships are:

Yenan Bryceson (https://ki.se/en/medh/yenan-bryceson-group): Cytotoxic lymphocyte biology in health and disease (Immunity, 2015; Immunity, 2017). Relevant projects:

  • Role of SAMD9/SAMD9L in control of viral infection and tumor cell proliferation
  • Understanding molecular mechanisms and improving diagnostics of primary immunodeficiency syndromes associated with predisposition to inflammation and cancer

Eva Hellström-Lindberg (http://ki.se/en/medh/eva-hellstrom-lindberg-group): MDS Research Lab (Oncotarget, 2016; Blood, 2017).

  • Reducing relapse rates after allogeneic stem cell transplantation in MDS through molecular stem cell surveillance and targeted clinical treatment.
  • Disease mechanisms in SF3B1 mutated MDS with ring sideroblasts (MDS-RS)

Sten Eirik Jacobsen (http://ki.se/en/medh/sten-eirik-w-jacobsen-lab-hematopoietic-stem-cell-biology-group): Normal and malignant hematopoietic stem cell biology (Nature, 2018; Nature Medicine 2017). Relevant projects:

  • Surveillance and immune-targeting (collaboration with Johanna Olweus, Science, 2016) of malignant stem cells in chronic hematological malignancies and following allogeneic transplantation
  • Modeling the impact of preleukemic and leukemic mutations on function of lineage-biased hematopoietic stem and progenitor cells cells

Robert Mansson (https://ki.se/en/medh/robert-mansson-group): Transcriptional and epigenetic control in normal and malignant hematopoiesis (Nat Immunol, 2015; Leukemia, 2018). Relevant projects:

  • Characterization of the dynamics of promoter-enhancers interactions in hematopoiesis and how these interactions are established in relation to differentiation and lineage restriction events.
  • Identification and functional characterization of non-coding mutations affecting distal gene regulatory elements in lymphoid malignancies.

Sidinh Luc (http://ki.se/en/medh/sidinh-luc-group): Functional differences between hematopoietic stem cell types and their epigenetic regulation (Cell Reports, 2016; Cell Stem Cell, 2013). Relevant projects:

  • Identification of critical epigenetic regulators for hematopoietic stem cell lineage bias
  • Characterization of the epigenetic landscape of lineage-biased hematopoietic stem cells

Seishi Ogawa (http://www.med.kyoto-u.ac.jp/en/organization-staff/research/doctoral_course/r-006/): Genetic analysis of evolution of myeloid neoplasms with myelodysplasia (Nature Genetics, 2017; New Engl J Med, 2016). Relevant projects:

  • A large-scale, unbiased analysis of genetic alterations in myeloid neoplasms (in collaboration with Eva Hellström-Lindberg)
  • Analysis of intratumor heterogeneity in MDS/AML using single-cell sequencing (in collaboration with Sten Eirik Jacobsen and Petter Woll)

Petter Woll (http://ki.se/en/medh/petter-woll-group): Cellular and molecular pathways promoting clonal advantage of (pre) leukemic stem cells (Cancer Cell, 2014; New Engl J Med, 2010). Relevant projects:

  • Single cell sequencing of genetically distinct cells within MDS hematopoietic stem and progenitor compartments (collaboration with Sten Eirik Jacobsen and Adam Mead, Nature Medicine, 2017)
  • Establishment and cellular origin of pre-leukemic stem cells and impact on lineage-fate in early hematopoietic stem and progenitor cells (collaboration with Professor Seishi Ogawa and Sten Eirik Jacobsen)

Duties
The research groups collaborate closely on these projects and the studies are conducted in mouse models and with relevant patient material. Key technologies applied towards these research questions include advanced flow cytometry, mouse genetics, high-throughput DNA and RNA sequencing including single cell analysis, and various in vitro and in vivo assays. Further details for each research group can be found at the indicated web homepages.

The research studies will be conducted in close cooperation with the group leaders, other scientists in the lab and external collaborators to jointly take the lead on the experimental work and data analysis of projects aiming to resolve cellular and molecular pathways regulating normal and malignant hematopoiesis. The scholarshipholder must enjoy team work and interact well with others, including other members of lab, as well as collaborating scientists and clinicians. Good communication skills will also be required for data presentations and to represent the group at local or external conferences.

Entry requirements
Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. Qualified to be admitted as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. The applicant can have a scheduled date for PhD-dissertation (in the mentioned subjects). In the latter case, however, the scholarship can only be approved once the applicant has been awarded his/her doctoral degree. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

Essential requirements

  • PhD degree, or PhD-dissertation scheduled, in which the latter require case verification from the Dissertation Committee (or equivalent body)
  • Strong track record as evidenced by one or more high impact publications in relevant research fields
  • Training in international leading laboratories
  • Previous experience in experimental application of molecular and cellular biology techniques in hematopoiesis or immunology
  • Good knowledge of spoken and written English
  • Excellent interpersonal and communication skills
  • Demonstrate ability to organize, plan and document experimental bench-work
  • Ability to stay on top of the relevant research field 

Desired requirements

  • Experience with advanced state-of-the art flow cytometry
  • Experience with next-generation sequencing analysis including RNA and DNA seq, ChIPseq, HiC, and similar assays as well as bioinformatics analysis and computational modeling based on such data
  • Experience with molecular analysis of small cell numbers, including single cell analysis

Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Application process
The application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A statement identifying which lab(s) the applicant is interested in
  • A maximum one page cover letter summarizing previous experience, research interest, and motivation for position
  • Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
  • Verification from the thesis defence committee or the equivalent
  • Names and contact details of three references that are familiar with the applicants recent research and training

The application is to be submitted on the Varbi recruitment system.

Type of employment Postdoktoralt stipendium
Contract type Full time
Number of positions 10
Working hours 100%
City Huddinge
County Stockholms län
Country Sweden
Reference number 2-1913/2018
Contact
  • Dimitra Vasileiadi, Research coordinator,, Dimitra.Vasileiadi@ki.se
Published 04.Apr.2018
Last application date 11.May.2018 11:59 PM CET

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