Karolinska Institutet, Institutionen för klinisk neurovetenskap

The Department of Clinical Neuroscience (CNS) conducts research and education in the field of neuroscience from the molecular level to the society level. The clinical research and education is conducted in collaboration with other research groups from the Karolinska Institutet, with other universities as well as the Stockholm County Council.
Please visit our website for more information: ki.se/en/cns

Division

Our laboratory is interested to further elucidate the physiological role of S100 proteins in sleep and the development and worsening of psychiatric disorders. Circadian and sleep disturbance is a common complaint of psychiatric disorders, and in most of the cases, they precede the pathology.  But despite their frequency, the role of circadian rhythm and sleep changes in the development of mental disorders still not well elucidated. Since the serotoninergic function is fundamental to the homeostasis of both, the S100 proteins family (related to psychiatric conditions, such as depression, and essential in serotoninergic function) becomes a candidate of study. Our focus will be on screening sleep and circadian rhythm patterns in animal models of depression and depression in PD and study the molecular mechanisms related to it. To achieve a better comprehension of how such changes, precede the disease, we plan to perform methylation studies in genes associated to sleep homeostasis and evaluation of underlying signaling pathways related to them, as well as protein levels measurement. Understanding the physiological function of sleep, the patterns of change in circadian rhythm in disease and the signaling pathways altered previous to the development of psychiatric disorders will open new avenues for development of novel therapeutic strategies. Thanks to the breadth of methodological approaches our laboratory is capable of translating results from molecular assays into the preclinical stage and further into clinical studies. 

Duties

The successful candidate will be responsible for running circadian rhythm screenings and shall have experience of EEG recording and analysis. Moreover, the candidate should have expertise in behavioral screening in animal models of depression. The applicant will also be responsible to evaluate the molecular mechanisms underlying the changes in sleep and circadian rhythm therefore, experience with methylation screening and high throughput transcriptional profiling, such as RNA sequence is necessary. Finally, we also expect that the he/she has some knowledge in bioinformatics to analysis and interpretation of data.

He/she will be encouraged to serve as mentors for PhD, bachelor and master students over the year. The applicant should show independency in his/her work but also to be a strong team player and motivated to work in a vibrant international and multidisciplinary research group. Establishment of national and international collaborations is highly encouraged.

Entry requirements

Applicant should have completed a Ph.D. in psychopharmacology or neuroscience and have between 4-5 years of postdoc experience within the field of Neuropharmacology. Working knowledge on the physiology of sleep, circadian rhythm, depression and PD disease is required. Hands on experience with animal behavior models of depression, EEG recording, as well as, extensive experience with methods of molecular biology such as RNA sequencing and qPCR are a prerequisite for this position. Knowledge with methods of molecular neuroscience, pharmacology and bioinformatics is advantageous. The successful applicant should have proven record in planning, implementing, managing and developing research projects as well as an experience in attracting and supervising students. Therefore, excellent communication skills and fluency in English language are highly preferred.

A person is eligible to be appointed Assistant professor if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence. The persons appointed should primarily be the ones who have been granted a Degree of Doctor or have reached the corresponding competence no more than five years before the end of the application period.

Bases of assessment
We stress scientific expertise when assessing applicants.

Application process
An application must contain the following documents in English or Swedish: Curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/qualificationsportfolio). 

The application is to be submitted through the Varbi recruitment system.

An Assistant professor position is a fixed-term position. The first employment should be two years, with a possible extension of two years after evaluation.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-1101/2018
Contact
  • Caisa Stilling, HR-administrator, 08-524 832 82
  • Per Svenningsson, Research group leader, per.svenningsson@ki.se
Union representative
  • Venus Azhary, OFR, 0707-124 127
  • Henry Wölling, SEKO, henry.wolling@ki.se
  • Arsalan Amir, SACO, 08 - 517 733 37, arsalan.amir@ki.se
Published 21.Feb.2018
Last application date 14.Mar.2018 11:59 PM CET

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