Karolinska Institutet, Institutionen för mikrobiologi, tumör- och cellbiologi

Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 100 PhD students, 50 postdoctoral researchers and 26 professors. Key words are multidisciplinary, bridging, translational, national and international collaborations.

Division
The laboratory is located at the department of Clinical Microbiology, Karolinska University Hospital, Solna and belongs to the department of Microbiology, Tumor and Cell Biology (MTC). The fact that the laboratory is located within the clinic in the hospital allows us to have close collaboration with clinicians.

Duties
We search for a post-doctoral fellow who can work together with Professor Annelie Brauner and her team within a project of innate immunity with focus on the host-microbe interaction with special focus on E. coli infections in the urinary tract.

Infection is a vast individual and socio-economic problem especially because of the increasing antibiotic resistance, which makes antibiotic treatment increasingly difficult. Among infections, urinary tract infections, often caused by E. coli belong to the top 10 infections, mainly in women and children. Interestingly, persons with underlying diseases such as diabetes mellitus frequently have recurrent urinary tract infections and severe infection complications, sometimes even life threatening septicaemia. From a global perspective, urinary tract infections are still the main cause of renal insufficiency. Based on the world wide increasing antibiotic resistance new treatment strategies are urgently called upon. We have previously demonstrated that the antimicrobial peptide cathelicidin, LL-37, is a key player to keep the urinary tract free from bacterial infection (Nature Med, 2006. Later we showed that vitamin D (PLOS One 2010) was able to increase cathelicidin and estrogen was able to increase several antimicrobial peptides in post-menopausal women (Science Transl Med, 2013). We continue exploring antimicrobial peptides. Focus of the project is to understand the underlying mechanisms of urinary tract infections in patients with diabetes, characterize novel targets targets to identify patients of risk to have severe infections and in the future design tailor made therapy for these patients.

The position includes primarily bacteriological and immunological methods including animal experiments with rodents. The most commonly used methods include bacterial culture, growth curves, analyses of bacterial virulence factors, biofilm assays, cell cultures and cell stimulation with bacteria, RT-PCR, ELISA, western blot, immunohistochemistry, confocal microscopy with imaging. Different mice species are infected, mainly transurethrally to cause urinary tract infections. Organs are used for bacterial culture, RT-PCR and immunohistochemistry.

Entry requirements
Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. Qualified to be admitted as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

The applicant must be able to work in team and be willing to collaborate and help others.

Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English:

  1. Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/meritportfolj )
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or studentorganisations, parental leave or similar circumstances

The application is to be submitted on the Varbi recruitment system.

Type of employment Postdoktoralt stipendium
Contract type Full time
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-1103/2018
Contact
  • Annelie Brauner, Professor, annelie.brauner@ki.se
Union representative
  • Daisy Hjelmqvist SACO, daisy.hjelmqvist@ki.se
  • Niklas Andersson, OFR, niklas.andersson@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
Published 22.Feb.2018
Last application date 15.Mar.2018 11:59 PM CET

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