Karolinska Institutet, Institutionen för fysiologi och farmakologi

At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

Research Group 
Research in our group revolves around biogenic amines in the brain: molecular biology, biochemistry and physiology, with special reference to drug development in neuropsychopharmacology.

Our research projects continue and extend our ongoing work aiming at the development of novel and improved pharmacological treatments of schizophrenia, major depression and tobacco dependence. These disorders represent some of the most costly medical problems known in the industrialized world, both at the level of the individual and at the level of the society.

In these studies, which originates in clinical problems and observations, we utilize an advanced set of basic scientific methodologies including transgenic mice, extra- and intracellular recordings, microdialysis and several behavioral techniques, in combination with various selective pharmacological tools to identify critical sites of action for new treatment strategies in this medical area.

The project and the duties of the research assistant
The purpose of this project is initially to study the recently discovered rapidly acting antipsychotic agent sodium nitroprusside (SNP), a nitric oxide donor which has a rapid onset, using behavioral methodologies as well as biochemical analysis of brain regions using microdialysis in rats and to compare SNP with molsidomine and nitroglycerin, another NO-donor, using the same methods, both when given alone and combined with antipsychotic drugs.

In another set of experiments we will begin to explore and develop a patentable novel inhibitor of indolamine 2,3 dioxygenase (IDO) for treatment resistant depression (TRD) as well as secondary or reactive depression.

In both projects the assistant will be involved with both planning and performing the experiments as well as analyzing the results. Results should be published in peer reviewed journals, moreover, the assistant should also present the obtained results at international Conferences.

Skills and personal qualities 
The applicant is expected to have finished a research master in life sciences, preferably with a strong focus on neuropsychopharmacology. The applicant should also have extensive experience (at least 1 year) in working with laboratory animals. Furthermore, a laboratory animals science certificate is considered as a definite advantage.

The applicant should be familiar with handling and injecting laboratory animals. In addition the applicant should be able to conduct good research practice and to perform standard laboratory tasks (making drug solutions, buffers etc.).

Furthermore, it would be desirable if the applicant has experience with behavioral pharmacology (elevated plus maze, open field test, T-maze, operant tasks etc.). In addition to this experience of using the cryostat to slice rat brains, as well as experience of staining brains is highly appreciated. Moreover, experience with surgical procedures in rodents is considered as an advantage.  

The application is to be submitted through the Varbi recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Reference number 2-764/2018
  • Håkan Westerblad, Prefekt, Hakan.westerblad@ki.se
Union representative
  • Niklas Andersson, OFR, Niklas.andersson@ki.se
  • Bo Rydqvist, SACO, Bo.rydqvist@ki.se
  • Henry Wölling, SEKO, Henry.wolling@ki.se
Published 12.Feb.2018
Last application date 26.Feb.2018 11:59 PM CET

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