Karolinska Institutet, Institutionen för medicin, Huddinge

The Department of Medicine, Center for Hematology and Regenerative Medicine
We are seeking a highly motivated and ambitious individual to join the research group of Yenan Bryceson as a Assistant Professor to further elucidate the molecular regulation of human NK cell memory.

Previously considered an arm of the innate immune system, recent studies from our group (Schlums, Cichocki et al., Immunity 2015; Corat, Schlums et al., Blood 2017; Schlums, Jung et al., Blood 2017) as well as others have uncovered NK cell memory processes. We have elucidated an epigenetic mechanism of diversification and specialization of human NK cells in response to cytomegalovirus infection. Mechanisms of innate immune memory currently represent a hot topic. A successful postdoctoral candidate will explore novel molecular aspects of human memory NK cell biology, derived from transcriptional and epigenetic analyses as well as insights from studies of primary immunodeficiency patients. Methods will involve advanced flow cytometry and sorting, single-cell RNA-seq, genetic manipulation, epigenetic and functional analyses. The objective of this research is it to better understand NK cell-dependent immunological memory and potentially harness cellular differentiation pathways for cellular immunotherapy of cancer.

The research group is based at the Center of Hematology and Regenerative Medicine (HERM), Karolinska Institutet. HERM consists of approximately 90 research fellows and is a nationally leading and internationally competitive environment for studies of the human immune system in the context of malignancy and infectious diseases. The vision is to become one of the leading translational research centers within hematopoiesis and immunity in Europe. The laboratory offers state-of-the art cell culture, molecular biology, flow cytometry and microscopy facilities. In the Bryceson group (http://www.ki.se/en/medh/yenan-bryceson-group), you will be working in a very international and interdisciplinary research environment, where collaborative efforts are encouraged.

You are expected to be a talented and enthusiastic researcher with a strong drive to perform basic research, playing an instrumental role in the elaboration of scientific hypothesis, experimental design, experimentation, data analysis and presentation/publication of results. You must be able to work within a team environment but retain enough independence to explore your results from a conceptual standpoint. You will be responsible for your own academic, research and administrative activities, adapt existing and develop new scientific techniques, test hypotheses and analyze data from a variety of sources.

Besides working on existing lab projects, postdocs are also encouraged to start their own new projects that can serve to launch their independent careers in science. Our aim is to provide a supportive environment conducive for development of independent scientists.

Entry requirements
A PhD in Immunology, Cell Biology, Hematopoiesis or related sciences is required, no more than seven years before the end of the application period, ideally with proven skills in cellular immunology and/or haematopoiesis research. Excellent spoken and written English is a requirement. A strong publication record is a merit. Applicants should have at least one first author publications in recognized peer-reviewed journals.

The position requires experience with multiparameter flow cytometry, sorting and/or high-throughput sequencing and advanced epigenetic analysis. Experience with bioinformatics, cell sorting, cell culture, and gene knockdown/transfection is an advantage. In addition, we believe that the successful candidate will have a strong background in immunology or hematopoiesis.

Good communication skills with the ability to present results clearly, work co-operatively as part of a team as well as independently with strong attention to detail are also essential. We will accord special weight to academic skills, particularly demonstrated excellence in research, a strong dedication, and excellent communication skills.

Bases of assessment
We stress scientific expertise when assessing applicants.

Personal qualities
The person should be well organized, service-oriented and flexible. A positive and collaborative attitude is a pre-requisite for working in the Bryceson group and a great emphasize is put on the collaborative attitude of the applicant. Thus, of importance is that the candidate is well acquainted with collaborative work in a dynamic environment which includes strong social skills.

Application process
An application must contain the following documents in English or Swedish: Curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/qualificationsportfolio).  The application is to be submitted through the Varbi recruitment system. An Assistant professor position is a fixed-term position. The first employment should be two years with a possible extension of two years after evaluation.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Huddinge
County Stockholms län
Country Sweden
Reference number 2-728/2018
  • Yenan Bryceson, yenan.bryceson@ki.se
Union representative
  • Yvonne Edlund OFR/ST , yvonne.edlund@ki.se
  • Mats Rudling, SACO, mats.rudling@ki.se
Published 05.Feb.2018
Last application date 15.Feb.2018 11:59 PM CET

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