Karolinska Institutet, Institutionen för onkologi-patologi, Forskargrupp Kallioniemi

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. 37 research groups with various cancer research profiles are involved and we have around 120 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

Research group Olli Kallioniemi
This position resides in the research group of Olli Kallioniemi, Director of Science for Life Laboratory, Professor of Molecular Precision Medicine, Dept. Oncology and Pathology, Karolinska Institutet. The group is located at the Science for Life Laboratory Solna Campus. The work will involve an opportunity to practice precision cancer medicine research in a translational setting, with the aim to assign and optimize targeted treatments for individual cancer patients. Our disease focus is on acute myeloid leukemia (AML), ovarian and urological tumors (prostate, kidney and bladder). Our goal is to develop a systems biology framework to match targeted therapies and drug combinations using genomic, transcriptomic and proteomic profiling along with functional ex vivo drug testing on primary patient-derived cells (PDC) from cancer patients. We work through team science in close collaboration not only with other research groups, but also with clinicians, as well as with different technology platforms of the SciLifeLab and Nordic and international collaborators. For more information: http://www.scilifelab.se/researchers/olli-kallioniemi.

Qualifications of The Applicant and Task Description
The successful candidate is an independent, creative and motivated individual with a documented ability to carry out experimental research projects, but also skilled in project management and leadership, grant writing and reporting, has excellent communication skills in spoken and written English. Experience in high throughput chemical biology, drug discovery or testing, HTS assay development or high content microscopy is necessary. The candidate should have experience in HTS and other data analysis, data quality control, data visualizations and data integration from large-scale data sets. Knowledge in small molecules and small-molecule probe design is required. We stress research expertise and demonstrated ability in collaborative team science when assessing applicants.

The tasks for this position involve the development of primary cell culture models of cancer and their drug testing assays, characterization of the models and comparison to human tumors as well as applications in precision cancer medicine in the clinical research setting and in the drug development projects. The candidate is also expected to carry out project management tasks such as contributing to grant writing, planning budgeting and reporting, monitoring milestones in a project, as well as interacting not only with research but also clinical and pharma collaborators.

- PhD in chemistry or biochemistry.
- Knowledge of cancer biology, precision cancer medicine and translational cancer research.
- Experience in high-throughput drug testing and assay development, including target engagement assays.
- Experience in working as part of large multidisciplinary, collaborative research projects (“team science”).
- Extensive experience in cell culture techniques, including experience with primary cell models.
- Knowledge of small molecule library design and small molecule probe development.
- Experience in project leadership and project management.
- Experience in large-scale data analysis and integration.
- Experience in data analysis workflows for high throughput screening, including data visualization, quality metrics and interpretation.

Application process
Application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labor unions or student organizations, parental leave or similar circumstances
  5. Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application.

The application is to be submitted through the Varbi recruitment system.

An Assistant professor position is a fixed-term position. The first employment should be two years, with a possible extension of two years after evaluation.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-614/2018
  • Päivi Östling, paivi.ostling@ki.se
Union representative
  • Mimmi Shoshan, SACO, 46 8 517 754 60
  • Andreas Lundqvist, SACO, 46 8 517 768 84, andreas.lundqvist@ki.se
  • Helen Eriksson, OFR, 46 8 517 762 79
Published 31.Jan.2018
Last application date 21.Feb.2018 11:59 PM CET

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