Karolinska Institutet, Institutionen för onkologi-patologi, Forskargrupp Lehtiö

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. About 30 research groups with various cancer research profiles are involved and we have around 110 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

Karolinska Institutet – Biological Mass Spectrometry Infrastructure
SciLifeLab is a collaboration effort between four universities in Stockholm and Uppsala: Stockholm University, Karolinska Institutet, Royal Institute of Technology (KTH) and Uppsala University. The center combines state-of-the-art equipment with a broad knowledge in translational medicine and molecular biosciences. From 2013 SciLifeLab have an assignment from the government to work as a national infrastructure and the vision is to make SciLifeLab a competitive center for high-throughput biosciences meant for research within health and environment.
BioMS is a national research infrastructure for biological mass spectrometry (www.bioms.se) shared between Karolinska Institutet (KI), University of Gothenburg (GU), Lund University (LU) and Chalmers University of Technology, to provide mass spectrometric support for national and international research projects. Each of the nodes is specialized in defined analytical technics and the KI node focus on chemical proteomics and proteogenomics. All the nodes work closely with each other to provide access and education within mass spectrometry to the entire Swedish research community. There is contantly exchange of resourses and knowledge between the nodes to provide cutting edge mass spectrometry capabilities, to develop and launch new support.
The national core facility in Stockholm is led by Professor Janne Lehtiö and located at the Science for Life Laboratory. The facility work in close collaboration with Prof. Lehtiö’s research group, where MS based proteomics methods are constantly developed and applied to studies aiming at improving individual cancer therapy. This collaboration is a prerequisite for the core facility’s ability to offer services at the forefront of MS based proteomics.

Job Description / Duties
The applicant’s main responsibility will be to work in BioMS, the national research infrastructure for biological mass spectrometry (www.bioms.se). The applicant’s role will be to work between the different BioMS nodes. The position will require that the applicant will spend time at and work closely with the University of Gothenburg’s node, to establish and adopt technologies in biological glycosylation analysis, in addition to the chemical proteomics and proteogenomics at the KI node.
The responsibilities accompanying this position include sample preparation, bio analytical work, analysis and reporting of protein/peptide expression, method development, use/optimization of the MS instruments, data analysis and data interpretation. A major aspect of this position involves laboratory work, thus experience in a laboratory is essential. The position may also include maintaining the instrument park; ranging from simple maintenance and calibration of LC-MS systems to more advanced troubleshooting and cleaning of instruments.
The role also includes report writing to BioMS users, providing undergraduate/postgraduate teaching modules and presentations/representation at national and international meetings and conferences.
The research engineer will be part of a large research infrastructure, working closely with project scientists, postdoctoral fellows, PhD-students, undergraduate students, and external users/customers within academia and industry. Important aspects of the job include:

  • Preparation of in vivo and in vitro samples
  • Experimental analysis of samples by mass spectrometry
  • Compiling and analyzing MS data
  • Continuous contact with customers by email and phone

The work involves a combination of flexible and routine tasks and places a great emphasis on independence, initiative, precision, and planning. The position involves a variety of tasks in a stimulating research environment. Nice and helpful colleagues contribute to a good working environment within the group.
A large part of the job may be contact with customers/researchers from a wide range of fields, which is an exciting, interesting and instructive part of the work.
We are seeking one (two) highly motivated research engineer scientist(s) for a 1-year position to be part of our biological mass spectrometry infrastructure.

The successful candidate should have:

  • MSc degree in analytical chemistry, biochemistry, biotechnology or in a related field
  • Documented background in MS-based proteomics or glycomics
  • Experience in glycomic data analysis and software´s for analysis, (UniCarb-DB and associated tools)
  • Extensive hands on experience in the laboratory
  • Extensive experience in operation and trouble-shooting of MS
  • Excellent communication and organizational skills
  • Good knowledge (both speaking and writing) of English


  • Competence/experience in MS-based clinical proteomics research
  • Technical experience in molecular biology and transfection techniques
  • Experience from chromatographic/electrophoretic isolation of glycoproteins/glycopeptides and released oligosaccharides
  • Experience in core facility work

We place great emphasis on personal suitability. To succeed in the role, it is important that the applicant is development oriented and has personal drive and patience. The applicant should be responsible, have a great sense of service, appreciate daily, detailed work as well as have the ability to see the big picture. The applicant should be an effective communicator, have good organizational skills, and be able to prioritize at times when the workload is high. The applicant should also be able to collaborate with people of different backgrounds and at different levels (both within the group and with users from various disciplines).

The application is to be submitted through the recruitment system Varbi.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
City Solna
County Stockholms län
Country Sweden
Reference number 2-5684/2017
  • Helena Bäckvall, 08 524 812 09, helena.backvall@scilifelab.se
Union representative
  • Andreas Lundqvist, SACO, 08 517 768 84, andreas.lundqvist@ki.se;
  • Helen Eriksson, OFR, 08 517 762 79
  • Mimmi Shoshan, SACO, 08 517 754 60
Published 05.Dec.2017
Last application date 15.Dec.2017 11:59 PM CET

Tillbaka till lediga jobb