Karolinska Institutet, Institutionen för medicin, Huddinge

Dep. of Medicine, Huddinge
The Department of Medicine, Huddinge conducted preclinical and clinical research in a variety of areas and undergraduate and graduate education. The department is internationally oriented and consists of seven units with about 40 teams.

The Center for Hematology and Regenerative Medicine (HERM; http://ki.se/en/medh/herm) is a new translational research center encompassing research groups involved in hematology, hemopoiesis, immunology and cell therapy.

HERM was created during 2011 with a mission to join research groups within hematology and hemopoietic cell therapy at Karolinska Institutet in a new translational research environment. The establishment of HERM was made possible through support from the Karolinska University Hospital and the Karolinska Institutet Wallenberg Institute of Regenerative Medicine (WIRM) and the Department of Medicine, Huddinge. HERM has an excellent structure and capacity for advanced cell culture and biobanking, and has with support from WIRM, established a new cutting-edge facility for flow cytometry.

Description of the research project/area of research
Applicants are invited to submit applications for a two year postdoc position.

The Woll group's (http://ki.se/en/medh/petter-woll-group) research focus is on cellular and molecular pathways governing the earliest fate decisions in normal hematopoiesis (Luc et al, Nat Immuol, 2012; Böiers et al, Cell Stem Cell, 2013; Sanjuan-Pla et al, Nature, 2013; Drissen et al., Nat Immunol, 2016) and how these are dysregulated in hematologic malignancies (Tehranchi et al, New Engl J Med, 2010; Mead et al, Cell Rep, 2013; Woll et al, Cancer Cell, 2014). This is studied in mouse models, as well as in relevant patients. Key technologies applied towards these research directions include flow cytometry, mouse genetics, high-throughput DNA and RNA sequencing including single cell analysis, bioinformatics and various in vitro and in vivo stem cell assays.

The research will be performed at HERM, a newly formed center at the Karolinska Institute aspiring to create a strong translational research environment bringing together basic and clinical scientists focusing on normal and malignant hematopoiesis.

Job description
The projects will be conducted under the supervision of Assistant Professor Petter S. Woll (http://ki.se/en/medh/petter-woll-group). Projects in Woll’s group, located at HERM, will focus on unraveling the normal cellular and molecular pathways governing lineage commitment from hematopoietic stem cells to lineage-restricted progenitors, during embryonic development as well as in adult hematopoiesis, and how these pathways are dysregulated in leukemic hematopoiesis. All projects will largely utilize mouse models of normal and malignant hematopoiesis but also have access to relevant patient material. The mouse models are primarily housed at Karolinska Institutetet’s Solna campus and the candidate will be required to travel between the two campuses on a regular basis.

The applicants are expected to take the lead on a high profile research project through active pursuit of relevant experiments, and through regular interactions with the group leaders and important collaborators within and outside the research institutes.

Entry requirements
Applications must be highly talented and enthusiastic researchers with a PhD degree (obtained no more than seven years before the last date of employment as postdoc) and a strong track record (evidence of one or more high impact publications in a relevant research field). Training in international leading laboratories is a merit.

Previous experience with relevant techniques in the specified areas is critical. In particular the applicant must have documented experience in state-of-the-art advanced flow cytometry analysis and ability to perform independent cell sorting on BD FACS instruments. The applicant must also have documented skills in mouse work, in particular ability to perform bone marrow aspiration from live mice. As a major part of the project will focus on next-generation sequencing (both DNA and RNA), the applicant must also have documented experience on successful generation of DNA and RNA sequencing libraries. The applicant must have ability to perform programming using Python for bioinformatics analysis. Experience in documentation and storage of experimental data is important. Applicants should have excellent interpersonal and communication skills, organizational skills to plan experimental bench-work, pedagogic skills required for training M.S. and PhD students, and the ability to work as part of a team as well as independently when required. Ability to stay on top of the relevant research field is an absolute requirement.

Good knowledge of spoken and written English is required.

Application process
An employment application must contain the following documents in English or Swedish:

A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page) Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline) Names and contact details of three references that are familiar with the applicants recent research and training

The application is to be submitted on the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Huddinge
County Stockholms län
Country Sweden
Reference number 2-5573/2017
  • Assistant Professor Petter S. Woll, petter.woll@ki
Union representative
  • Yvonne Edlund OFR/ST , yvonne.edlund@ki.se
  • Mats Rudling, SACO, mats.rudling@ki.se
Published 29.Nov.2017
Last application date 08.Dec.2017 11:59 PM CET

Tillbaka till lediga jobb