The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

Division
The Rheumatology Unit, at the Department of Medicine, Solna, is an active and internationally successful research unit. Here clinical, experimental and epidemiological research is conducted in close collaboration with the rheumatology clinic at the Karolinska University Hospital, Solna. The unit has a leading role in several national and international consortia and networks. Work will be conducted in Dr. Caroline Grönwall’s research group that has a focus on understanding the pathogenesis of autoimmune disease with a special interest in B-cells and autoreactive antibodies.

Duties
We are looking for a motivated scientist for a position for a postdoctoral researcher with an interest in combining clinical immunology with high-throughput biotechnology methods. The project is primarily focused on studies of B-cell/autoantibody repertoires in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis to increase our knowledge about pathogenesis. The work will involve developing new methods for isolating human monoclonal autoantibodies from patients with autoimmune disease and surveys of B cell repertoires. This includes working with single-cell technologies and next-generation sequencing. The work may also involve serological surveys, re-formatting of antibodies and testing inflammatory activities in cellular assays. While the main duties are conducting experimental research, the duties may also include administrative tasks (such as ordering and organization) and responsibilities in supervising students and personnel. 

Entry requirements
The candidate must hold a PhD in a relevant discipline, immunology, biotechnology or equivalent. The applicant should have experience of molecular biology techniques such as generation of DNA constructs, PCR, sequencing, protein expression and protein analysis. Knowledge in antibody engineering, B-cell biology, cell assays, clinical immunology and/or rheumatology is beneficial. Similarly, experience of next generation sequencing, and data analysis is meriting. The applicant must be willing to work with human blood and tissue samples.

A successful candidate is expected to be open to learning new methods, be responsible, have a positive attitude, function well in team environment and have a good ability for problem solving and independent work. Strong communication skills in and proficiency in written and spoken English are a necessity.

A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100
City Solna
County Stockholms län
Country Sweden
Reference number 2-5379/2017
Contact
  • Caroline Grönwall, caroline.gronwall@ki.se
Union representative
  • Lars Ährlund-Richter, SACO, 08 - 5177 34 50, lars.ahrlund@ki.se
  • Nasrin Bavand, 08-517 723 64
Published 20.Nov.2017
Last application date 10.Dec.2017 11:59 PM CET

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