Karolinska Institutet, Institutionen för medicin, Huddinge

We are seeking a highly motivated and ambitious individual to join the research group of Mattias Carlsten as a Postdoctoral Fellow to elucidate the potential of genetic engineering of donor lymphocyte grafts to improve treatment of post-transplant leukemia relapse.

Research group                                            
Assistant Professor Dr. Mattias Carlsten M.D. Ph.D. (http://ki.se/en/people/mattca) was recently recruited from the National Institutes of Health (NIH) and is currently expanding his translational research group at the Karolinska Institute. The group is located at HERM, Department of Medicine, Huddinge (MedH), Karolinska Institutet (http://ki.se/medh/herm). The main research focus of Dr. Carlsten’s group is to study how the immune system can be utilized to treat cancer (Carlsten et al. Clin. Can. Research 2016, Carlsten et al. Frontiers in Imm. 2016, Childs et al. Nature Reviews Drug Discovery 2015). More specifically, the group focuses its work around basic biology and genetic engineering of natural killer (NK) cells with the overall aim of applying new discoveries in settings of cellular cancer immunotherapy. As a physician-scientist, Dr. Carlsten’s work is stretched from pre-clinical in vitro studies, including bench work and animal models, to early clinical trials involving cellular cancer immunotherapy and immunomodulating drugs. The group is now also starting up a research arm focusing on transplantation biology including therapies for patients with post-transplantation leukemia relapse.

Project description
The project will focus on genetic engineering of lymphocytes for improved bone marrow homing of donor lymphocyte infusion (DLI) grafts. The aim is to improve the tumor rejection capacity of DLIs while reducing the risk of DLI-induced graft-versus-host disease in non-bone marrow organs. The position provides an exciting opportunity for the successful candidate to apply cutting-edge technology and work towards establishing the concept of genetic engineering of DLI grafts for improved therapeutic efficacy with the overall aim of providing proof-of-concepts for clinical translation of the approach. The work will involve cell and molecular biological assays as well as in vivo mouse experiments.

Entry requirements
We are seeking a highly talented and enthusiastic researcher with a Ph.D. degree and a background in immunology and animal work as well as a strong track record. Candidates with extensive experience in performing immune assays and adoptive cell transfer into mice are welcome to apply. Knowledge in tumor immunology, stem cell transplantation, graft-versus-host disease (GvHD), including grading of GvHD in mice, animal imaging and gene modification of cells is preferable. State-of-the-art experience with multiparameter flow cytometry and analysis is a merit.  

The successful candidate should have excellent interpersonal and communication skills, organizational skills, and the ability to work productively and dynamically in a team. Self-motivation and the ability to stay on top of the relevant research field is an absolute requirement. Applicants must be able to integrate well into the international and multidisciplinary research environment. Excellent knowledge of spoken and written English is a requirement.

Postgraduates who have yet to graduate may apply if their thesis defense is scheduled to take place within four months after the application deadline, in which case verification from the Dissertation Committee, or equivalent body, must be submitted with the application.

Postdoctoral scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. This is a full-time fixed-term appointment for 24 months, with possibilities for extension depending on scientific progress.

Application process
The application must contain the following documents in English:

Cover letter, including a summary of the Ph.D. studies (no more than two pages). A complete Curriculum Vitae, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position and academic distinctions. A complete list of publications.
 Verifications for crediting of illness, military service, work for labor unions or student organizations, parental leave or similar circumstances. Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within four months after the application deadline). Names and contact details of three references who are familiar with the applicant’s recent research and training.

The application is to be submitted through the MyNetwork recruitment system.

The Department of Medicine, Huddinge, conducts preclinical and clinical research in a variety of areas and undergraduate and graduate education. The department is internationally oriented and consists of seven units with a total of nearly 60 research groups, including three research centres. Our ambition is to be the leading department for medical research and education.

Research environment
The Center for Hematology and Regenerative Medicine (HERM) at the Department of Medicine, Huddinge, consists of approximately 90 research fellows and is a nationally leading and internationally competitive environment for studies of the human immune system in the context of malignancy and infectious diseases. At HERM, the groups are part of a highly interactive research environment within basic immune cell biology, cellular immunotherapy along with cellular and molecular regulation of hematopoiesis in health and disease. HERM is also tightly connected with clinical researchers and healthcare teams at several departments of the Karolinska University Hospital, including Center for Hematology, which allows for research involving clinical material and the potential to bring new therapies from bench to bedside. The laboratories at HERM offers state-of-the art cell culture, molecular biology, flow cytometry and microscopy facilities. The vision is to become one of the leading translational research centers within hematopoiesis and immunity in Europe

Type of employment Postdoktoralt stipendium
Contract type Full time
Number of positions 1
Working hours 100%
City Huddinge
County Stockholms län
Country Sweden
Reference number 2-4536/2017
  • Assistant Professor, Dr Mattias Carlsten, mattias.carlsten@ki.se
Union representative
  • Yvonne Edlund OFR/ST , yvonne.edlund@ki.se
  • Mats Rudling, SACO, mats.rudling@ki.se
Published 05.Oct.2017
Last application date 02.Nov.2017 11:59 PM CET

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