Karolinska Institutet, Institutionen för onkologi-patologi, Forskargrupp Lehtiö

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. 37 research groups with various cancer research profiles are involved and we have around 120 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

Description of work place
The position will be placed in the Cancer proteomics Mass spectrometry research group at Science for Life Laboratory (SciLifeLab). The group is headed by Professor Janne Lehtiö, who is heading the group and a proteomics facility at KI and SciLifeLab. SciLifeLab is a collaboration effort between four universities in Stockholm and Uppsala: Stockholm University, Karolinska Institutet, Royal Institute of Technology (KTH) and Uppsala University. The center combines state-of-the-art equipment with a broad knowledge in translational medicine and molecular biosciences. From 2013 SciLifeLab have an assignment from the government to work as a national infrastructure and the vision is to make SciLifeLab a competitive center for high-throughput biosciences meant for research within health and environment. The Stockholm node of SciLifeLab is composed of a large number of groups, which formally belongs to a department at one of the three universities in Stockholm or are taking part through an industrial collaboration.

Description of research group/core facility
Lehtiö group is a translational group of scientists with a drive to improve human proteome analysis by developing new methods that are applied to improve personalized cancer treatment. Our group includes researchers and staff from various disciplines working as a team to gain new knowledge. Our main focus is on cancer proteome analysis. Proteomics is a research field aiming to study proteins on a systems level by simultaneous analysis of thousands of proteins. We aim to gain new knowledge on proteins in the context of biological networks, to discover biomarkers and understand how genome changes impact the proteome level. We are engaged in method development projects to improve tissue and plasma proteomics for example using high resolution peptide isoelectric focusing (HiRIEF) coupled to mass spectrometry analysis, improve post translational modification analysis, subcellular relocalisation analysis and targeted proteomics to increase sensitivity and throughput in clinical validation of proteomics data.

We now need to strengthen our group with a postdoc within the field of proteomics method development.

Area of responsibilities/duties
We are looking for an outstanding postdoc that together with Prof. Janne Lehtiö and co-workers will work on mass spectrometry-based proteomics projects. The focus will be on development and application of quantitative proteomics methods for biologically/clinically oriented research questions and to analyze the acquired mass spectrometry data. The Post Doc will plan and perform mass spectrometry based proteomics experiments, with a focus on the analysis and interpretation of complex proteomics data. This includes both to apply established data analysis steps as well as to investigate new strategies and solutions for the analysis of quantitative omics data, such as for example pathway analysis level analysis for biological interpretation. Experimental design and statistical analysis of the quantitative data are important components of the work, and it is expected that the applicant is acquainted with software related to omics data analysis. The applicant should further be acquainted with the available techniques for quantitative mass spectrometry.

The employment is a 1 year position with possibility to further employment. We offer a very stimulating and diverse work in a team of very motivated co-workers.


  • PhD in biology, medicine or other related relevant field
  • Documented experience in MS-based proteomics
  • Knowledge of cancer biology and current translational cancer research
  • An understanding of cell- and molecular experimental methods
  • Experience of collaboration between different disciplines
  • Excellent communications skills
  • Good knowledge in English, oral and written

Additional merits

  • Experience of tools for biological interpretation and visualization, such as Ingenuity Pathway analysis, DAVID, etc
  • Teaching and presenting scientific data
  • Ability to work independently

Since the position involves close interaction with several researchers, emphasis is placed on personal skills such as:

  • Very good collaborative skills
  • Excellent communication skills and analytical skills
  • Curious and eager to solve biological questions

Application process
An employment application must contain the following documents in English or Swedish:

  1. Application letter
  2. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  3. A complete list of publications
  4. A summary of current work (no more than one page)
  5. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-4514/2017
  • Janne Lehtiö, Professor, 08-52 481 416, janne.lehtio@ki.se
  • Helena Bäckvall, 08-52 481 209, helena.backvall@ki.se
Union representative
  • Andreas Lundqvist, SACO, 08-517 768 84, andreas.lundqvist@ki.se;
  • Mimmi Shoshan, SACO, 08-517 754 60
  • Helen Eriksson, OFR, 08-517 762 79
Published 05.Oct.2017
Last application date 14.Oct.2017 11:59 PM CET

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