Department of Medicine, Solna, Clinical Epidemiology section

The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

Unit of Clinical Epidemiology
Research at the Clinical Epidemiology Unit (KEP) combines clinical, epidemiological, and biostatistical expertise with the aim to improve the understanding and treatment of a broad range of medical conditions. We focused on translational research studies to improve prediction of disease onset, treatment effects, and disease outcomes.

We are seeking a bioinformatician/computational biologist to support research activities in the field of gastrointestinal disease (PI Mauro D’Amato,, with focus on inflammatory bowel disease (IBD) and biomarker discovery through computational data integration and high-throughput patient’s molecular profiling.

The successful candidate will take on the processing, quality control, pre-analysis and analysis of a variety of high-throughput molecular data (genetic, epigenetic, transcriptomic, proteomic etc) coming from large cohort of Swedish treatment-naïve IBD patients and patients at treatment initiation with biologics. He/she is also expected to contribute the development of analytical strategies aimed at leveraging the complexity of multi-omics data, in order to assess the impact of genetic variants on multiple regulatory dimensions, from transcriptional to post-translational. He/she will also be responsible for the reporting of project results to colleagues within the consortium, and collaborators and peers at international meetings.

The position is available immediately for 2 years (till the end of 2019), with the possibility for extension depending on available funds.

Entry requirements

  • - PhD in Bioinformatics or related area.
  • - Experienced user of R/Bioconductor, Python and programming languages. Use of version control systems and dynamic report generation. Unix environments and high-performance computing clusters.
  • - Demonstrated knowledge of bioinformatic and computational approaches to the study of human genetics and “omics”, and good understanding of “biology” (biological questions)
  • - Demonstrated ability to work with different type of genetic, epigenetic (DNA methylation, miRNA), proteomic, transcriptomic data, and large complex datasets (GWAS, EWAS etc)
  • - Good knowledge of omics data integration methods and meta-analyses
  • - Additional background in statistics, machine learning and/or predictive analytics is a plus
  • - Team-work attitude, impeccable organizational skills, and previous participation in international research activities/projects/publications
  • - Excellent spoken and written English.

A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.

Application process
An employment application must contain the following documents in English

  • - A letter of interest, also outlining how the candidate’s experience and background fulfills the specific duties and entry requirements.
  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100
City Solna
County Stockholms län
Country Sweden
Reference number 2-4509/2017
  • Mauro D'Amato ,
Union representative
  • Lars Ährlund-Richter, SACO, 08 - 5177 34 50,
  • Nasrin Bavand-Chobot, OFR,
Published 09.Oct.2017
Last application date 31.Oct.2017 11:59 PM CET

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