At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. 37 research groups with various cancer research profiles are involved and we have around 120 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

Research group
Martin Enge was recently recruited from Stanford University to the department of Oncology-Pathology, where he studies clonal evolution, gene regulation and cell interaction in cancer using novel single-cell methodology. Our research aims to study these processes in cells from intact patient or mouse tissue, which allows us to reverse-engineer cancer as a complex disease influenced by both tumor cell heterogeneity and stromal interactions. We are recently established at the department, and the candidate will play an active part in shaping the setup of the team. More information on Martin Enges’s group can be found here: http://ki.se/en/onkpat/research-team-martin-enge. The current projects rely on unpublished methods, but for prior work see for example Enge et al., Cell 2017, Chakravarthy H et al., Cell Metab. 2017, Katainen et al., Nat. Genet 2015,  Yan, Enge et al., Cell 2013.

Project description
Stem cells are perpetually renewing cell populations essential for organ homeostasis, but stem-like cells exist also in tumors, where they play a key role in therapy resistance and metastasis. Stem cells require a supporting niche, consisting of adjacent epithelial and stromal cells. However, the properties of tumor stem cells and their niche are still not well understood, due to technical limitations of studying these rare and poorly defined cell populations.
The successful candidate will study single cells from primary tissue using novel single-cell methods that allow us to address the effects of genetic defects on transcription, as well as characterizing the stem cell niche in normal and tumorigenic tissues.

Qualifications and entry requirements
We are looking for a highly driven scientist, with an interest in shaping future single-cell methodology and cancer biology. The candidate should already have a strong scientific record in the form of high-impact scientific publications, and be comfortable with independently pursuing scientific questions. The project is multidisciplinary in nature, and the ideal candidate is comfortable with, and interested in learning, both molecular biology and computational biology methods. Also, we rely heavily on collaborations with clinicians, which the successful candidate will be expected to manage. Proficiency in written and spoken English is necessary.
A person is eligible for a two-year tax-free postdoctoral fellowship/scholarship, if he or she has obtained a PhD in a relevant discipline no more than two years before the first date of employment as postdoc.

Application process
An application must contain the following documents in English:
1) A complete curriculum vitae including the date of the thesis defense, title of the thesis, current position, academic awards and distinctions
2) A complete list of publications, with the top two publications clearly marked
3) A summary of previous and current work (one page, font 12)
4) Verifications for crediting of illness, military service, work for labor unions or student organizations, parental leave or similar (if relevant)
5) Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline)
6) Two letters of recommendation


The application is to be submitted on the MyNetwork recruitment system.

Type of employment Postdoktoralt stipendium
Contract type Full time
Reference number 2-4494/2017
Contact
  • Martin Enge, martin.enge@ki.se
Union representative
  • Andreas Lundqvist, SACO, 46 8 517 768 84, andreas.lundqvist@ki.se;
  • Mimmi Shoshan, SACO, 46 8 517 754 60
  • Helen Eriksson, OFR, 46 8 517 762 79
Published 09.Oct.2017
Last application date 20.Nov.2017 11:59 PM CET

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