Karolinska Institutet, Institutionen för mikrobiologi, tumör- och cellbiologi, Schlisio

Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 81 PhD students, 77 postdoctoral researchers and 32 professors. Key words are multidisciplinary, bridging, translational, national and international collaborations.

The Schlisio lab at Karolinska Institute and Ludwig Institute, Sweden, seeks postdoctoral fellow and/or bioinformatician, to work on the computational analyses of a large-scale single-cell transcriptome project on childhood neuroblastoma and pheochromocytoma.

For more information about the group see: http://ki.se/en/people/suschl and http://www.ludwigcancerresearch.org/location/stockholm-branch/susanne-schlisio-lab

How and when during development does childhood neuroblastoma (NB) and pheochromocytoma (PCC) arise? We aiming to elucidate the origin and heterogeneity of human neuroblastoma (NB) and pheochromocytoma (PCC). NB is a cancer of early childhood that arises from the developing sympathetic nervous system births that despite its relative rareness accounts for 15% of childhood cancer mortality. While primary NB tumors occur in sympathetic neural tissue, most commonly arising in the adrenal medulla their precise origin is poorly understood. In pediatric tumors such as NB the underlying developmental processes are considered to be important, and NB can be considered as a failure of differentiation of neural crest cells underscoring the importance of understanding this process as it proceeds normally.

The clinical hallmark of childhood neuroblastoma is heterogeneity, ranging from spontaneous regression to relentless progression. The cell of origin is thought to be a developing sympathoblast. However, its precise cell of origin remains unknown and the genetic basis of neuroblastoma remains obscure. Identifying the developmental cell of origin will reveal the causes of disease heterogeneity and clinical behavior. Understanding what triggers spontaneous neuroblastoma regression would provide critical clues for the development of therapeutic strategies that are currently missing in high risk neuroblastoma.

We are looking for one outstanding researcher to work on the computational analyses of a large-scale single-cell transcriptome project on neuroblastoma and pheochromocytoma. In this project we will generate “molecular encyclopedias” of this tumor in order to understand the molecular principles concerning the origin, progression and subtypes of this tumor at a previously unprecedented level, using state-of-the-art RNA-seq and bioinformatics technologies. Therefore, we seek one postdoctoral research fellow with expertise in computational analyses of RNA-seq data and OMICS data.

Entry requirements
The postdoctoral fellow in computational analyses of single-cell RNA-seq data should have a strong background in genome-wide bioinformatics, programming and linux environment. Previous experience with RNA-seq data analyses is required and additional experience with single-cell data, post-transcriptional gene regulation (e.g. splicing) or machine learning is a strong merit.

Successful applicants must have the ability to work both independently and collaboratively in a group and have good English communication skills.

Application process
An employment application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A CV including complete list of publications
  3. A summary of current work (no more than one page) and your research interest
  4. 2 reference letters

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-4468/2017
  • Susanne Schlisio, susanne.schlisio@ki.se
Union representative
  • Henry Wölling, SEKO, 08-524 840 80, henry.wolling@ki.se
  • Daisy Hjelmqvist, SACO, daisy.hjelmqvist@ki.se
  • Niklas Andersson, OFR, niklas.andersson@ki.se
Published 30.Oct.2017
Last application date 17.Nov.2017 11:59 PM CET

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