Karolinska Institutet, Institutionen för biovetenskaper och näringslära, Andersson (EAN)

The Department of Biosciences and Nutrition performs research and education in several areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. It offers an excellent international research and working environment, including around 300 scientists, students, administrative and technical personnel. The Department resides in the new biomedical research building Neo, aimed at being a creative and open environment that enables meetings, synergies, and exploration of areas of mutual interest across disciplines.

Division
microRNAs (miRs) fine-tune mRNA stability and translation, acting as molecular dials during development and in cancer. In spite of their crucial function, little is known of how microRNAs discriminate between different bona fide targets. In this project, funded by an extremely competitive Wallenberg grant, we have assembled an international team of bioinformaticians, structural biologists and physical chemists to elucidate how miRs chose the targets and determine their fate. We are now searching for a postdoctoral candidate to join the Andersson lab (www.anderssonlab.com), with experience in wet-lab work, working with microRNAs to validate and test real-world targeting.  Together with Katja Petzold’s group (http://www.petzoldlab.com), the group investigates the roll of sequence and structure of microRNAs in controlling their mRNA “targetome”, in development of the embryo.

For more info, see also:https://kaw.wallenberg.org/sma-molekyler-styr-hjarnans-utveckling-och-cancer (website in Swedish).

The postdoctoral researcher will belong to the department of Bioscience and Nutrition (Bionut), Huddinge campus. As the Andersson lab also has a laboratory at the department of Cellular and Molecular Biology (CMB), at the Karolinska Institutet Solna campus, close collaboration with the Solna campus, and the Petzold lab in the Department of Medical Biochemistry and Biophysics, will be facilitated.

Since 2008, Dr Andersson has published 20 articles and reviews, and has an H-index of 15 (ISI Web of Science). She is the Chair of Karolinska Institutet’s Junior Faculty, and has been awarded several prizes, including the Sven and Ebba Christina Hagberg Award, and the 2017 Daniel Alagille Award from the European Association for the Study of the Liver (EASL). 

Duties
The postdoctoral project entails studying targeting of an array of mRNAs by a microRNA, using qPCR, luciferase assays, single cell transcriptomics and single cell proteomics. Studies will be performed in vitro (in cell culture) and in vivo (in mouse embryos). Close collaboration with bioinformaticians, structural biologists and physical chemists will aim to elucidate a structure-function code.

Qualifications
We are looking for a curious, driven and creative person with an interest in microRNAs, embryonic development and disease. An ability to take initiative and good communication skills are a merit. The candidate must have experience in wet-lab work, working with microRNAs to validate and test real-world targeting. Position-specific requirements are;  

  • A PhD degree in microRNA biology or similar field
  • A strong background in microRNA biology, including detection and quantification of microRNAs, quantification of mRNA target abundance, luciferase assays for determination of seed sequence specificity, or IP of for example Argonaut for microRNA loading.
  • Strong background in cloning, plasmid production, cell culture, transfection methods.
  • Since the project entails work with animals, experience in laboratory animal work, specifically mice, is a merit.
  • Excellent written and oral communication in English

Entry requirements
Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English:

  • CV max. 3 pages, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work.
  • Verification from the thesis defense committee or the equivalent (only if the thesis defense is scheduled within three months after the application deadline)
  • Copies of degree certificate and associated certificates.
  • Complete publication list with links to degree project and any previous publications
  • Contact information of two references, recommendation letters are also welcome.
  • A letter of motivation (max. 1 page)
  • A summary of current work (max. 1 page).

The application is to be submitted on the Varbi recruitment system.

Type of employment Postdoktoralt stipendium
Contract type Full time
Reference number 2-4385/2017
Contact
  • Emma Andersson, Assistant Professor, +46-8-524 80000
  • Thomas Tinglöv, Head of Administration, +46-8-524 835 49
Union representative
  • Joseph Rafter, SACO, +46-8 - 524 83 545
  • Henry Wölling, SEKO, +46-8-524 840 80
  • Birgitta Lindqvist, OFR, +46-8-524 810 28
Published 27.Oct.2017
Last application date 17.Nov.2017 11:59 PM CET

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