Karolinska Institutet, Institutionen för onkologi-patologi, Forskargrupp Holmgren

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. 37 research groups with various cancer research profiles are involved and we have around 120 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

The position is placed in the research group of Prof. Lars Holmgren at Cancer Centre Karolinska, CCK.

Project background
Transmission of mechanical force via cell junctions is an important component that molds cells into shapes consistent with proper organ function. Of particular interest are the cadherin transmembrane proteins that play an essential role in connecting cell junctions to the intra-cellular cytoskeleton. Understanding how these biomechanical complexes orchestrate intrinsic and extrinsic forces is import for our understanding of the underlying mechanisms driving morphogenesis. We have previously identified the Amot protein family, which are scaffold proteins that integrate polarity, junctional, and cytoskeletal cues to modulate cellular shape. Using genetic inactivation approaches in endothelial cells, zebrafish and mice we have characterized the function of the protein family in normal development as well as in tumor progression. We have shown that AmotL2 associates to VE and E-cadherin and is part of machinery that relays force between cells via the formation of para-cellular actin filaments. Our data show importance of this type of force transmission for blood vessel function, blastocyst formation and cancer (http://ki.se/ki/jsp/polopoly.jsp?l=en&d=10258&a=130074).

Area of responsibilities/description of the work
We aim to study the role of the Amot family of proteins in development and cancer. This family of proteins was discovered by the group and has been shown to be involved in cell migration, polarity, cytoskeletal rearrangement and cell-cell contact formation. The successful candidate will be involved in setting up experiments and analyzing results in mouse KO models that recently has been established. These include retinal angiogenesis as well as tumor progression in breast cancer.

To qualify, the applicant must hold a doctor’s degree or a foreign qualification deemed equivalent to a doctorate in a relevant field. The applicant must have more than 3 years of experience in experimental research and be well educated in the areas of developmental biology, tumor biology, confocal imaging.

The position will be fixed to one year with possibilities for prolongation with one year. Applicants will be evaluated on the following criteria:

1) Education and previous training
2) Relevance for the project
3) Publication and track record
4) Motivation

Entry requirements
Scholarships to pursue postdoctoral studies may be awarded to individuals who come from other countries with the intention of remaining in Sweden only while obtaining all or part of their education. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher. Having received a salary or other remuneration from Karolinska
Institutet during the past two years may be disqualifying.

One requirement for receiving a scholarship for postdoctoral studies is central registration as a postdoc.

Type of scholarship
Karolinska Institutet awards scholarships to pursue postdoctoral studies. This educational scholarship, which is paid for a maximum of two years within four years after the receipt of a PhD or the equivalent, is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English:

1. Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/meritportfolj)
2. A complete list of publications
3. A summary of current work (no more than one page)
4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted on the MyNetwork recruitment system.

Type of employment Postdoktoralt stipendium
Contract type Full time
Reference number 2-4129/2017
  • Lars Holmgren, 46 08 517 793 17
Union representative
  • Andreas Lundqvist, SACO, 46 08 517 768 84, andreas.lundqvist@ki.se
  • Mimmi Shoshan, SACO, 46 08 517 754 60
  • Helen Eriksson, OFR, 46 08 517 762 69
Published 24.Nov.2017
Last application date 04.Dec.2017 11:59 PM CET

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