Karolinska Institutet, Institutionen för onkologi-patologi, Forskargrupp Lehtiö

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. 37 research groups with various cancer research profiles are involved and we have around 120 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

Description of the work group/equivalent
Science for Life Laboratory (SciLifeLab) is a collaboration effort between four universities in Stockholm and Uppsala: Stockholm University, Karolinska Institutet, Royal Institute of Technology (KTH) and Uppsala University. The centre combines state-of-the-art equipment with a broad knowledge in translational medicine and molecular biosciences. From 2013 SciLifeLab have an assignment from the government to work as a national infrastructure and the vision is to make SciLifeLab a competitive centre for high-throughput biosciences meant for research within health and environment.

The Cancer proteomics Mass spectrometry research group at SciLifeLab (Stockholm) is equipped with the latest peptide separation techniques and mass spectrometry instrumentation. The research group is also closely associated with the regional Clinical Proteomics Mass Spectrometry facility that provides fee-for-service sample analysis as well as support to plan and perform larger in-depth proteomics project. The research group is also associated with the National Infrastructure for Biological Mass Spectrometry (www.bioms.se) that provides MS-support in whole Sweden.

The Cancer proteomics Mass spectrometry group develop and use proteomics methods to improve personalized cancer therapy. Proteomics is a research field aiming to study global changes in a proteome, such as to determine the function of a specific protein in the context of a biological network or to discover biomarkers.

We are currently engaged in projects to analyze the proteome landscape of several different cancer types including lung cancer, with the aim to identify and validate key pathways, novel biomarkers and drug targets. In addition we are developing and applying methods for functional proteomics through post translational modification analysis and subcellular proteomics. Here the aim is to describe the activity and subcellular localization of proteins as well as relocalization of proteins during certain conditions.

We now need to strengthen our group with a Researcher in Applied Proteomics and Cancer Proteomics. The employment is a permanent position with a trial period of 6 months.

Area of responsibilities/duties
We are looking for an outstanding Researcher in Applied Proteomics and Cancer Proteomics. In addition to maintaining an independent research track, the researcher should serve part time as the head of facility for the Clinical Proteomics Mass Spectrometry facility at the Lehtiö research group.

Tasks for the position:

  • Manage projects and serve as an expert in applied proteomics and cancer proteomics for the research groups projects
  • Maintain an independent and internationally competitive research program
  • Supervise postdocs, graduate students and technical personnel in research projects on applied proteomics and cancer proteomics
  • Apply for external funding - both national and international
  • Actively participate in academic, industry and health care collaborations involving MS-based proteomics methods to improve cancer therapy
  • Head the Clinical Proteomics Mass Spectrometry facility at the Lehtiö research group

We offer a very stimulating and diverse work in a team of motivated co-workers.

Entry requirements
A person is eligible to be appointed Researcher if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence, as well as documented research after publicly defending his or her doctoral thesis corresponding to qualification as Assistant professor.


  • PhD in biology, medicine or other related relevant field.
  • Relevant international postdoctoral experience.
  • Several years of postdoctoral experience in proteomics-based mass spectrometry
  • Extensive knowledge of cancer biology and translational cancer research.
  • Documented knowledge and practical experience of developing MS-based proteomics methods.
  • Expertise in proteomics and proteogenomics analysis.
  • Expertise in systems biology/systems medicine, large-scale data analysis, integration and visualization.
  • A solid understanding of cell- and molecular experimental methods.
  • Experience of collaboration between different disciplines.
  • A proven academic track record, including high-impact and highly cited publications and leadership and teaching record.
  • Experience in core facility work.
  • Good knowledge in English, oral and written.

Additional merits

  • Expertise in omics bioinformatics.
  • Experience in high-throughput phenotypic drug testing.
  • Extensive project management expertise, as well as practical project management including budget planning and follow-up, personnel planning, grant writing and reporting.

Since the position involves close interaction with several researchers, emphasis is placed on personal skills such as:
-Very good collaborative and pedagogic skills
-Excellent communication skills and analytical skills.

Bases of assessment
In assessing the candidates, suitability for the position, experience in the above specified methods, research quality, as well as supervision of doctoral students and postdoctoral projects, and cooperation at international level, will form the basis for the selection of this recruitment.

Application process
The application should include:
- Application letter
- Curriculum vitae, qualifications and description of planned research, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/qualificationsportfolio). 
- A selection of five scientific papers
- Publication list (with five most relevant publications marked)

The application is to be submitted through the MyNetwork recruitment system.  

At Karolinska Institutet a 6-month trial period is required for all permanent appointments.

Type of employment Tillsvidareanställning
Contract type Full time
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-3855/2017
  • Janne Lehtiö, Professor, +46-8-52481416, janne.lehtio@ki.se
Union representative
  • Andreas Lundqvist, SACO, +46-8-517 76884, andreas.lundqvist@ki.se;
  • Mimmi Shoshan, SACO, +46-8-517 75460
  • Helen Eriksson, OFR, 46-8-517 76279
Published 25.Aug.2017
Last application date 17.Sep.2017 11:59 PM CET

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