Karolinska Institutet, Institutionen för medicin, Huddinge

A doctoral position is an available doctoral education project to which a PhD student is to be recruited. After the selection process the process for admission to doctoral education will commence. An admission decision will not be taken until an individual study plan has been approved by the departmental admission board.

For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral

The Cell and Gene Therapy Group in Department of Medicine Center for Hematology and Regenerative Medicine is announcing the creation of a doctoral student position at Karolinska Institutet within the research fields of Hematology, Cancer Immunotherapy and Gene Therapy.

Research group
We are offering one PhD position in The Cell and Gene Therapy Group (CGTG). The primary project supervisor will be Assistant Professor Evren Alici. The PhD student will be working at Center for Hematology and Regenerative Medicine (HERM), a new translational research center encompassing research groups involved in hematology, hematopoiesis, immunology, and cell therapy. CGTG has internationally-recognized leadership in clinical grade, current good manufacturing practice (cGMP)-compatible manufacturing of cellular and gene therapy applications. Furthermore, CGTG has been involved in a large number of clinical trials, including the first gene therapy clinical trial in Sweden as well as the first Swedish clinical trials assessing the safety of both patient and donor derived ex vivo expanded NK cells in patients with various malignancies.

The doctoral education project and the duties of the student
NK cells are a small lymphocyte population capable of tumor cell killing. Multiple myeloma accounts for approximately 10% of all hematological malignancies with a median survival rime of only 6 years. In the first and the second project, the aim will be to optimize multiple myeloma cell killing by NK cells through genetherapy or antibody targeting both in vitro and in vivo. The third project will aim to generate and test oncolytic virotherapy in tumors. These projects will include cell biology and molecular biology, several in vitro methods as well as in vivo experiments.

We are seeking a highly motivated student to work on projects focused on NK cells and cancer research. You should like team-work and international contacts, yet be prepared to assume responsibility to deliver on your own parts in the project and fulfil the requirements of the doctoral training program.

Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:

General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  1. has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education

Skills and personal qualities
The applicants are expected to be talented and enthusiastic researchers with a strong research drive. Authorship on research articles is highly meritable, as is previous training in research laboratories, preferably at international well-known institutes. Prior experience with cell culture, molecular biology, in vivo models and flow cytometry is desirable. The candidates are expected to elaborate in scientific hypotheses, experimental design, experimentation, and presentation/publication of results. The candidate must be able to work within a heterogeneous and multicultural team environment but retain independence to explore their own hypotheses and results, and drive their own projects. Personal suitability will be a strong selection criterion.

Assessment criteria
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months.

Application process
An application must contain the following documents in Swedish or English:

    • A personal letter and curriculum vitae
    • A copy of degree certificates and associated certificates
    • A copy of degree projects and any previous publications
    • A set of character references that will serve as confirmation of good character

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Doktorandplats
Contract type Full time
Reference number 2-3683/2017
  • Assistant Professor/Group leader Evren Alici, evren.alici@ki.se
Union representative
  • Yvonne Edlund OFR/ST , yvonne.edlund@ki.se
  • Mats Rudling, SACO, mats.rudling@ki.se
Published 11.Aug.2017
Last application date 25.Aug.2017 11:59 PM CET

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