The Department of Microbiology, Tumor and Cell Biology (MTC), carry out research aimed to unravel mechanisms underlying the development of cancer and immune-mediated diseases as well as to develop new strategies to fight infections and cancers globally. The science at MTC includes both basic and clinically anchored research and many projects build on long-standing national and international collaborations. MTC has about 430 active employees, including 81 PhD students, 77 postdoctoral researchers and 32 professors. Key words are multidisciplinary, bridging, translational, national and international collaborations.

Division

MTC offers an opportunity for postdoctoral research studies. The research activities in our (Aspenström)group are aimed to elucidate various aspects of cell signalling mediated by small GTPases, primarily the Rho GTPases. This group of proteins has emerged as key regulators of cell morphogenesis, cell migration and cell polarity but they also participate in signalling pathways that control cell growth, cell cycle progression and cell survival. We have previously shown that this family of proteins consists of 20 members and that their cellular effects are more intricate and complex than previously recognised. Our goal is to identify how signalling involving small GTPases contribute to processes such as cell migration, cell growth, mitochondrial function and tumour progression. A key challenge for the near future will be to identify the precise mechanisms by which a multitude of extracellular and intracellular signals, via the activity of small GTPases, can be translated into highly specific physiological responses.

Duties

The current project for research studies will focus on the Miro GTPases, which are a group of proteins originally discovered by the Principal Investigator. The Miro GTPases are key players in mitochondrial homeostasis and functioning. Their importance in a physiological context also makes them significant proteins in the pathology of neurodegenerative diseases. Both proteins are suggested to be linked either directly or via downstream signalling partners to the disease progression of Alzheimer’s and Parkinson’s diseases. The overarching aim of this project is to enhance the understanding of the function and the role of Miro GTPases in neurodegenerative diseases.

Entry requirements

We are seeking a highly motivated, responsible and independent researcher with a PhD degree awarded within the past three years in cell biology, neuroscience or in a related research topic.

The applicant should have a strong background in molecular cell biology. Practical experience of standard cell biology techniques, including advanced microscopy and live cell imaging, is a prerequisite. Experience of studies in neurodegenerative disease models is a meritorious factor.

Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis.

Application process
An application must contain the following documents in English:

  1. Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/meritportfolj )
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or studentorganisations, parental leave or similar circumstances
  5. A brief letter of motivation (no more than one page)
  6. Contact details for two reference persons.

The application is to be submitted on the MyNetwork recruitment system.

Type of employment Postdoktoralt stipendium
Contract type Full time
Reference number 2-3497/2017
Contact
  • Pontus Aspenström, professor, pontus.aspenstrom@ki.se
Union representative
  • Nasrin Bavand-Chobot, OFR, Nasrin.Bavand@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
  • Daisy Hjelmqvist, SACO, daisy.hjelmqvist@ki.se
Published 13.Jul.2017
Last application date 10.Sep.2017 11:59 PM CET

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