At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

Division and Project Description
Tumor cells display metabolic profiles that are remarkably distinct from their normal tissue of origin. This is to ensure fulfillment of their higher bioenergetic/biosynthetic needs required to support rapid proliferation. Less is known about metabolic heterogeneity in seemingly identical cancer cells. We have previously identified metabolic heterogeneity in lymphomas and could show that based on our metabolic profiling, unique metabolic dependencies can be rationally targeted (Cancer Cell. 2012 and Trends in Cell Biology. 2014, and Cell Death Differentiation. 2017). We identified a layer of metabolic diversity in lung adenocarcinomas recently and showed that it could be targeted based on its metabolic dependencies (Cell Reports, 2017, Journal of Cancer, 2017). Our group focuses on understanding basic mechanisms underlying metabolic heterogeneity. To this end, we are currently trying to identify molecular regulators that shape tumor metabolism and metabolic diversity, with the ultimate goal of identifying novel drug targets and biomarkers.  

To study these questions we employ a translational approach including primary patient material paralleled by studies to elucidate the molecular mechanisms in cancer cells, normal cells and cancer mouse models. We are using an integrative approach consisting of metabolomics, proteomics and transcriptomics as well as various genetic, biochemical and molecular biological tools. 

For more information please see our recently published work:

Cell Reports 2017 Jun 13;19(11):2289-2303.
Journal of Cancer 2017;8(1).
Cell Death Differentiation. 2017 Feb;24(2):251-262 .
Biochem Biophys Res Commun. 2017 Jan 15;482(3):426-431.
Biochem Biophys Res Commun. 2015 May 8;460(3):572-7.
Trends Cell Biol. 2014 Feb;24(2):118-27.
Cancer Cell 2012 Oct;22(4):547-60.

Duties
The applicant will conduct research within the field of molecular cancer research with a focus on Tumor metabolism. The project will have a central focus on identifying novel molecular regulators of tumor metabolism by using siRNA screening methodology. The ultimate goal is to target the identified metabolic regulators and to study its impact on tumor cell survival.

Entry requirements
Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

Qualifications
Applicants must have a Ph.D. in Medical Sciences or related discipline(s) including Biochemistry or Molecular Biology.

We seek exceptional, dedicated, highly motivated and hardworking individuals with considerable experience in cell and molecular biology as well as biochemistry. The candidate should have a strong background in cancer biology and have documented experience in cancer biology (as shown by first-author publications in international peer-reviews journals), experience with cell culture and transfection techniques incl. siRNA and overexpression methods, the ability to work independently, and to work on multiple projects simultaneously.

The candidate must be willing to work ambitiously and effectively in a collaborative environment with a strong commitment to research. Successful candidates must have great proficiency in English communication skills.

Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English:

  1. Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/meritportfolj )
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or studentorganisations, parental leave or similar circumstance.
  5. Provide a motivation letter including career goals, relevant experience for the project etc. (no more than one A4 page).
  6. Reference letters from at least two previous employers and their contact information.

The application is to be submitted on the MyNetwork recruitment system.

Type of employment Postdoktoralt stipendium
Contract type Full time
Reference number 2-3464/2017
Contact
  • Erik Norberg, group leader, Erik.Norberg@ki.se
Union representative
  • Bo Rydqvist, SACO, 08-524 872 67, bo.rydqvist@ki.se
  • Magnus Anå, OFR, 08-524 864 37, magnus.ana@ki.se
  • Henry Wölling, SEKO, 08-524 840 80, henry.wolling@ki.se
Published 10.Jul.2017
Last application date 04.Sep.2017 11:59 PM CET

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