The Department of Molecular Medicine and Surgery (MMK) carries out both preclinical and clinical research within numerous fields. Linked to the department are approximately 450 researchers, postgraduate students, teachers and technical & administrative staff and we currently have about 150 PhD students. The department is conducting undergraduate courses for medical students, physiotherapist students, biomedicine students and biomedical laboratory students.

Division

Neurogenetics

Our aims are to identify molecular factors that (a) predispose to the development of neuropsychiatric disorders and (b) predict response to treatment. We perform both preclinical and clinical intervention studies and have ongoing studies on psychosis, bipolar disorder, ADHD and anorexia. The research group consists of ~15 clinicians, molecular biologists and chemists and we are located in the Center for Molecular Medicine (CMM).  Read more http://ki.se/en/mmk/neurogenetics

Description of the position

The subject of the position is to develop a broad range of in vitro cell culture models to study adolescent and adulthood psychiatry, addressing cellular aspects of basic brain functions in mental health or illness, including cellular, molecular, biochemical, neurodevelopmental and pharmacological aspects. Special research interest should be focused on how dopaminergic neurons are involved in the etiology and progression of psychiatric disorders. This includes generation of induced pluripotent stem cells from patients, establishment of neural stem cell lines, and differentiation of stem cells into brain cells including dopaminergic neurons in both two-dimensional cell monolayers and three-dimensional brain organoid cultures. All this expertise should converge in the scientific management of a core facility for human organoids and stem cell research.

Duties
To conduct leading research in cellular psychiatry and be the scientific manager of a human organoid core facility. This also includes seeking funding for research in open competition, teaching activities such as supervision of master students, doctoral candidates and postdoctoral fellows, course management, course administration and other administrative activities in the unit.

Eligibility

The applicant must

  • hold a doctor’s degree in Biochemistry, Molecular Biology, Cellular Biology or similar scientific area or a foreign qualification deemed equivalent to a doctorate.
  • have excellent knowledge in modern biochemistry and molecular biology techniques along with immunohistochemistry and a good knowledge of cellular and confocal microscopy analysis.
  • have his/her own established research line driving innovative and advanced technologies, including human pluripotent stem cells, neural stem cells and neuronal differentiation in both two-dimensional cell monolayers and three-dimensional brain organoid cultures, within the area of in vitro cell culture models in psychiatry.
  • have broad and deep knowledge in dopaminergic neurogenesis, the transcriptional regulatory network that control dopaminergic neurons, and long experience generating dopaminergic neurons from human stem cells.
  • have experience of managing a core facility for human organoids and stem cell research. 
  • have documented experience of successful supervision of doctoral students and pedagogic training.
  • have obtained, as the principal applicant, external funding in recent years.

Special priority will be given to applicants that are developing new exploratory hypotheses to understand how the environment and environmental pollutants are influencing the development of psychiatric diseases.

Entry requirements
A person is eligible to be appointed Senior Researcher if he or she has been awarded a Degree of Doctor or has achieved the corresponding scientific competence, as well as documented research after publicly defending his or her doctoral thesis corresponding to qualification as Assistant professor.

Assessment

When selecting amongst eligible applicants, weight will primarily be given to the scientific merits, the research plan and the experience of designing a core facility for human organoids and stem cell studies and, and thereafter to teaching expertise and to administrative activity.

Furthermore, consideration will be given to the ability to acquire funding for research in competition, as well as the demonstrated capacity to interact with others both within academia and in industry.

In assessing teaching and administrative activities, any activity including lecturing, supervision of students, capacity to plan, coordinate group members, academic evaluation, funding initiatives, core facility coordination, scientific publishing, will be considered.
We stress research expertise when assessing applicants.

Application process

The application must comprise the following documents, written in English:

  • A personal letter (maximum 1 page). Curriculum Vitae, describing qualifications, achievements and grant support (maximum 3 pages).
  • Research plan (maximum 5 pages including figures and references).
  • A brief written account of scientific, teaching and administrative activity (maximum 2 pages).
  • A complete publication list with separate sections for original peer reviewed publications and other types of publications.
  • Doctoral diploma, Certificates and other documents referred to in the application 

The application is to be submitted through the MyNetwork recruitment system.  

At Karolinska Institutet a 6-month trial period is required for all permanent appointments.

Type of employment Tillsvidareanställning
Contract type Full time
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-3410/2017
Contact
  • Martin Schalling/ Professor, martin.schalling@ki.se
  • Catharina Lavebratt /Forskare, catharina.lavebratt@ki.se
Union representative
  • Michael Tekle, SACO, 08-517 73442, michael.tekle@ki.se
  • Nasrin Bavand-Chobot, OFR, Nasrin.Bavand@ki.se
  • Elisabeth Noren-Krog, OFR, 08- 517 70478
Published 05.Jul.2017
Last application date 30.Jul.2017 11:59 PM CET

Tillbaka till lediga jobb