Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Chemistry II

Area of responsibilities/description of the work
We have an opening for an individual wishing to join a multidisciplinary project aimed to investigate the role of lipid mediators in inflammation. The successful candidate will be expected to use and further develop mass spectrometry-based methods for metabolic profiling of lipid mediators (e.g., prostaglandins, leukotrienes, endocannabinoids) and related molecules in a range of biological matrices (e.g., blood, sputum, saliva). Analyses will involve a combination of clinical cohorts as well as experimental models to map the biochemical role of lipid mediators in the pathobiology of inflammation. This project will involve working closely with collaborators at the Karolinska University Hospital as well as the University of Barcelona. Particular emphasis will be placed on investigating omega 3 fatty acid-derived lipids termed specialized pro-resolving mediators (SPMs: protectins, resolvins, and maresins). These compounds are thought to possess pro-resolution properties, with protective effects in inflammatory diseases.
The mechanisms of these effects remain mostly unknown, but are of significant interest for their potential therapeutic applications.

The successful applicant will belong to the Integrative Molecular Phenotyping laboratory (http://metabolomics.se) in the Department of Medical Biochemistry and Biophysics. The Department has a strong and internationally recognized research tradition in the physiology and pathobiology of bioactive lipids, including awarding of the Noble Prize for the discovery of eicosanoids. The research environment includes working with state-of-the-art equipment, including multiple mass spectrometers. This full-time position is temporary (two years), with potential for renewal for at least 2 more years.

We are looking for highly motivated candidates with a Ph.D. in quantitative mass spectrometry or bioanalytical chemistry. The successful candidate will be expected to use and further develop mass spectrometry-based methods for metabolic profiling of lipid mediators. Accordingly, applicants need to document their experience in small molecule mass spectrometry by LC-MS/MS. We are especially interested in candidates with prior experience working with eicosanoids or other bioactive lipid mediators in inflammatory systems. Experience in cell culture and FACS analysis would be a significant merit as is experience with multivariate statistics, biomedical training, clinical research or studies of metabolism. Excellent communication skills and an ability to interact socially and scientifically with other post docs and students in the laboratory, and with collaborators in various networks are essential. Previous post doc experience and a strong publication record are also strong merits.

Entry requirements
A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-2986/2017
  • Craig Wheelock, Ph.D, +46 (0)8-524 876 30
Union representative
  • Anne Edgren, OFR/S, P, O, 08-616 16 29
  • Biborka Bereczky Veress, SACO, 46 70-173 85 75 , biborka.bveress@ki.se
  • Henry Wölling, SEKO, 08-524 840 80, henry.wolling@ki.se
Published 14.Jun.2017
Last application date 31.Aug.2017 11:59 PM CET

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