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Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 81 PhD students, 77 postdoctoral researchers and 32 professors. Key words are multidisciplinary, bridging, translational, national and international collaborations.


The Schlisio lab at Karolinska Institute and Ludwig Institute, Sweden, seeks postdoctoral fellows, to work on molecular mechanisms of oxygen sensing and cancer.

Our research concerns the mechanisms of how disruption of oxygen-sensing pathways can lead to cancer. Oxygen sensors enable the cell to adapt to low-oxygen environments and are critical for normal development and apoptosis. These events are often disrupted in the development of tumors. Oxygen sensing is mediated partly via prolyl hydroxylases that require molecular oxygen for enzymatic activity. Our work focuses on how prolyl hydroxylases execute apoptosis in neural precursors during development and how disruption of this process can lead to certain forms of nervous-system tumors.


(1) We are seeking a motivated, creative post-doctoral candidate interested in tumor mouse models arising from the sympatho-adrenal lineage, such as neuroblastoma and pheochromocytoma, with the aim to understand the molecular principles of these tumors at a previously unprecedented level.

(2) Furthermore, we are looking for motivated, creative post-doctoral candidates interested in cancer metabolism with knowledge in basic biochemistry and molecular biology. We currently defining how oxygen sensing regulates mitochondrial dynamics and mass.

(3) In addition, we are looking for one outstanding researcher to work on the computational analyses of a large-scale single-cell transcriptome project on neuroblastoma. In this project we will generate “molecular encyclopedias” of this tumor in order to understand the molecular principles concerning the origin, progression and subtypes of this tumor at a previously unprecedented level, using state-of-the-art RNA-seq and bioinformatics technologies. Therefore, we seek one postdoctoral research fellow with expertise in computational analyses of RNA-seq data and OMICS data.

Entry requirements
A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.

Successful applicants must have the ability to work both independently and collaboratively in a group and have good English communication skills.

Position-specific requirements:

The postdoctoral fellow in computational analyses of single-cell RNA-seq data should have a strong background in genome-wide bioinformatics, programming and linux environment. Previous experience with RNA-seq data analyses is required and additional experience with single-cell data, post-transcriptional gene regulation (e.g. splicing) or machine learning is a strong merit.

Application process
An employment application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page) and your research interests.
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
  5. 2 reference letters, send to : Susanne.Schlisio@ki.se

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 3
Working hours 100 %
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-2938/2017
  • Susanne Schlisio, Associate Professor, Susanne.Schlisio@ki.se
Union representative
  • Nasrin Bavand-Chobot, OFR, Nasrin.Bavand@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
  • Daisy Hjelmqvist , SACO, daisy.hjelmqvist@ki.se
Published 13.Jun.2017
Last application date 18.Jul.2017 11:59 PM CET

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