At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

A doctoral position is an available doctoral education project to which a PhD student is to be recruited. After the selection process the process for admission to doctoral education will commence. An admission decision will not be taken until an individual study plan has been approved by the departmental admission board.

For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral

Research Group
Renal, Cardiovascular and Metabolic Research

Research Profile: http://ki.se/en/people/matcar 

Project Title: Targeting microvascular oxidative stress in cardiovascular and renal disease

Cardiovascular disease and associated renal dysfunction are major health problems, affecting more than one billion people worldwide. Oxidative stress implies increased production or decreased scavenging of reactive oxygen species (ROS), which is often associated with nitric oxide (NO) deficiency. NADPH oxidase (NOX)-derived superoxide (O2•−) is a major source of renal and vascular ROS, and increased NOX activity has been reported in the development or progression several disorders. This translational project aims to explore and further characterize the novel concept that imbalance between NOX-derived O2•− and NO signaling in the microvasculature plays a key role in cardiovascular and renal disease.

Inorganic nitrate (NO3-) and nitrite (NO2-) have long been considered inert end products of NO metabolism. However, we and other groups have shown that these anions, which are found in high concentrations in green leafy vegetables, via serial reduction steps can undergo bioconversion to NO independently of endothelial NO synthase (eNOS). This project aims to further investigate the therapeutic value of boosting the NO3--NO2--NO pathway. We hypothesize that this novel strategy can correct microvascular oxidative stress by modulating ROS and NO generation, and hence halt progressive inflammation.

The research team has developed and has access to a broad, novel and advanced methodological platform to investigate novel signaling pathways in cardiovascular and renal disease. Unique combination of experimental and clinical studies in healthy subjects and patients with the disease will be utilized in this project, which will result in novel mechanistic insights and ability to rapidly translate knowledge into practice.

The doctoral education project and the duties of the student 
The project is at the forefront of NO and ROS research, and focus on potential therapeutic actions of nitrate and nitrite. The PhD student will have access to a broad and comprehensive research platform, and experience a translational experimental approach. This project will provide the student with a deep knowledge in experimental in vitro and in vivo techniques together with understanding on how to conduct clinical studies that will be valuable for the future career.

Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:

General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  1. has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education

Skills and personal qualities
Previous experience and training with the use of rodent disease models, assessment of renal and cardiovascular functions in vivo and ex vivo analyses of vascular function will be an asset for this project. Previous experience in redox signaling, oxidative stress, inflammation, histology, immunohistochemistry is also desirable. External grants as scholarship for doctoral students will also be considered.

Assessment criteria
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months.

Application process
An application must contain the following documents in Swedish or English:

  • A personal letter and curriculum vitae
  • A copy of degree certificates and associated certificates
  • A copy of degree projects and any previous publications

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Doktorandplats
Contract type Full time
Reference number 2-2822/2017
Contact
  • Mattias Carlström. group leader, Mattias.Carlstrom@ki.se
Union representative
  • Bo Rydqvist, SACO, 08-524 872 67, bo.rydqvist@ki.se
  • Henry Wölling, SEKO, 08-524 840 80, henry.wolling@ki.se
  • Magnus Anå, OFR, 08-524 864 37, magnus.ana@ki.se
Published 09.Jun.2017
Last application date 04.Aug.2017 11:59 PM CET

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