The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

Division
The Rheumatology Unit, Solna, is an active and internationally successful research unit. Here clinical, experimental and epidemiological research is conducted in close collaboration with the rheumatology clinic at the Karolinska University Hospital, Solna. The unit has a leading role in several national and international consortia and networks.

Work will be conducted in the research group of Dr. Fredrik Wermeling that has a focus on finding new treatment strategies for cancer and autoimmune diseases. For more information please visit http://ki.se/en/meds/autoimmune-and-inflammatory-diseases-novel-treatment-strategies or https://wermelinglab.com/.

Duties
The focus of the postdoctoral position relates to anti-inflammatory properties of the STAT6 signaling pathway, with an emphasis on myeloid cells in a cancer setting (See Wermeling et al, 2013, PNAS; and Anthony, Kobayashi, Wermeling et al 2011, Nature). A major focus also relates to antibody mediated effector functions (e.g. related to treatments with tumor-specific antibodies).

Animal models for autoimmune and inflammatory disease as well as cancer, and human patient material are extensively used in the research group. Methods such as flow cytometry and sorting, signaling and gene expression analysis, cell culture and molecular biology techniques including CRISPR/Cas9 are central to the work in the group.

Entry requirements
We seek a highly motivated candidate with a demonstrated record of scientific excellence.

The successful applicant must have an extensive experience working with various animal models for cancer, and using therapeutic antibodies in the cancer setting. Experience studying how cytokines and various signaling pathways, especially STAT6, affects the progression of tumor growth, as well as the activity of therapeutic antibodies is highly valued.

Experience working with anti-inflammatory myeloid cells; e.g. tumor associated macrophages (TAMs) and Myeloid-derived suppressor cells (MDSC) is highly valued. Experience working with antibody mediated effector functions (e.g. related to Fc gamma receptors) is valued. Experience with CRISPR/Cas9 is highly valued.

We welcome a creative, hardworking and enthusiastic team-player to our group. The candidate is expected to partake in experimental design, experimentation, presentations, and preparation of publications. Personal suitability and scientific expertise is highly valued. The applicant must hold a PhD in Molecular Biology/Biomedical Sciences or equivalent and be proficient in English, both spoken and written.

The position is for one year with possible extension and we aim to fill the position as soon as possible.

A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100
City Solna
County Stockholms län
Country Sweden
Reference number 2-2539/2017
Contact
  • Fredrik Wermeling, 08-51774087
Union representative
  • Lars Ährlund-Richter, SACO, 08 - 5177 34 50, lars.ahrlund@ki.se
  • Nasrin Bavand-Chobot, OFR, Nasrin.Bavand@ki.se
Published 19.May.2017
Last application date 29.May.2017 11:59 PM CET

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