The research group Signal Tranduction at the Department of Molecular Medicine and Surgery is interested in complex signal-transduction in pancreatic islet cells under physiological and diabetic conditions. In recent years, the group has established the innovative and versatile approach “Non-invasive in vivo imaging of pancreatic islet cell biology” and successfully pioneered its application in in vivo characterization of signal-transduction in islet cells and other cells. Research areas of the group include insulin receptor signaling, inositide signaling, voltage-gated Ca2+ (CaV) channels, intracellular Ca2+ oscillations, stress signaling, serum factors and pancreatic islet cell plasticity. Read more http://ki.se/en/mmk/signal-transduction-0
One of our ongoing, long-term projects is the understanding of the beta-cell signaling machinery in vivo. It aims to gain in depth understanding of beta-cell function in vivo and possible changes in the signaling cascade under diabetic conditions. Most of the work is carried out using in vivo microscopy, which is complimented with animal physiology experiments and immunohistochemistry. The project strives to generate mechanistic knowledge on beta-cell function and survival and to develop innovative therapeutic approaches against diabetes. The successful applicant will join and enhance ongoing efforts in beta-cell research focusing on the physiology and pathophysiology in primary rodent and human beta-cells in vivo.
The applicant should have a PhD degree within the area of biomedical research. He or she must have deep theoretical and practical knowledge on beta-cell physiology and especially Ca2+ signaling. The applicant must be skilled at multidisciplinary techniques including cell culture, islet isolation and transplantation, animal physiology, fluorescence labeling and two-photon/confocal microscopy, in vivo imaging, Ca2+ imaging, PCR, adenovirus handling, protein biochemistry, insulin secretion assay, animal perfusion, whole mounts and basic image processing. He or she should demonstrate his or her ability to deal with multiple projects simultaneously, solve problems independently and interact well with group members. The applicant should be able to design and carry out her or his own projects.
A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances
An employment application must contain the following documents in English or Swedish:
The application is to be submitted through the MyNetwork recruitment system.
|Type of employment||Visstidsanställning längre än 6 månader|
|Contract type||Full time|
|Number of positions||1|
|Working hours||100 %|
|Last application date||07.May.2017 11:59 PM CET|