Division of Neurogeriatrics
The Division is focused on translational research in neurodegenerative diseases, in particular Alzheimer disease.
The Scientific Project and the Research Group
The project aims to harness the BRICHOS domain for treatment of Alzheimer disease. We have found that the BRICHOS domain has a unique mechanism of action – it redirects the fibrillation pathway so that generation of toxic oligomers from the amyloid β-peptide (Aβ) is markedly reduced. Recent data show that recombinant BRICHOS has different activities depending on its structure, and we will now study in detail the structures and activities of biochemically different forms of BRICHOS. Currently the groups have about 20 members including professors, senior scientists, post-docs and graduate students with a broad international background.
The candidate is expected to have a strong drive to pursue experimental research, and an ambitious and innovative attitude. The projects are pursued in collaboration with several research groups, and good collaborative skills are necessary. Good ability to speak and write English is also a requirement.
A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances. A PhD in biology, biotechnology or similar topic is required. The final candidate needs to have strong experience of working with recombinant protein expression and purification, and a good knowledge of biochemical and biophysical experimental techniques for studies of self-assembling proteins, eg amyloidogenic peptides and spider silk proteins. Experience from experimental studies on protein self-assembly and molecular chaperones is qualifying.
Please contact Prof. Jan Johansson (email@example.com, tel +46-703457048) at the Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, 141 57 Huddinge, Sweden for further information.
An employment application must contain the following documents in English or Swedish:
The application is to be submitted through the MyNetwork recruitment system.
|Type of employment||Visstidsanställning längre än 6 månader|
|Contract type||Full time|
|Number of positions||1|
|Last application date||06.Apr.2017 11:59 PM CET|