The Department of Medicine, Solna, is one of the largest departments at Karolinska Institutet. The department consists of several units that are separated into different research groups. The core activities of the department are research, doctoral education and undergraduate education for medical and biomedical students. The research has three main profiles: allergy, cardiovascular medicine and inflammatory diseases.

The Petter Brodin research group located at Science for Life Laboratory in Stockholm and affiliated with the unit of infectious diseases, Karolinska Institutet, develops and applies experimental and computational research methods for systems-level analyses of human immune systems. The aim of the group is to understand human immune system variation in health and disease (Brodin & Davis, Nat. Rev Imm 2017) and the regulatory mechanisms underlying such variation and adaptation to environmental influences (Brodin et al, Cell 2015). A particular focus of the group is to understand immune systems development in early life.

The current project will be focused on the analysis of epigenetic imprinting of human immune cells during the first weeks and months of life. To this end, we have established a unique birth cohort followed with longitudinal blood samples during the first three years of life. We are FACS-sorting immune cells and analyzing epigenetic changes by ATAC-seq (Buenrostro, et al Nat Methods, 2013). The data has already been generated and the current project is focused on analyzing longitudinal changes in epigenetic signatures and comparing these between children facing different environmental conditions. Another important focus of the current position is the development and application of novel single-cell data analysis methods for the analysis of mass cytometry data acquired from the same time-points from these children.

Skills and personal qualities
The successful candidate should have a PhD in the physical or life sciences. The successful candidate must be thriving in interdisciplinary environments, able and comfortable to work independently, being results oriented and able to meet deadlines. The candidate must have excellent communication skills in English. Experience of analyzing various types of transcriptomic or genomic datasets, generated by sequencing-based methods is important. Experience in analyzing ATAC-seq data in particular is ideal, but not an absolute requirement. Strong knowledge and experience of high-dimensional data analysis, statistics and machine learning is essential, preferably using Python and/or R languages, given the use of these languages in our existing data analysis pipelines.

Assessment criteria
A selection will be made among qualified applicants on the basis of the following criteria:

  • Documented subject knowledge of relevance to the area of research
  • Expressed interest in the proposed project
  • Other documented experience relevant to the subject and planned project

 The qualifications of the applicants will be evaluated on an overall basis.

Entry requirements
A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances. The position will be in the form of a 2+2 year postdoctoral employment.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100
City Solna
County Stockholms län
Country Sweden
Reference number 2-1345/2017
  • Petter Brodin, 08-524 813 96
Union representative
  • Lars Ährlund-Richter, SACO, 08 - 5177 34 50,
  • Nasrin Bavand-Chobot, OFR,
Published 17.Mar.2017
Last application date 09.Apr.2017 11:59 PM CET

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