Applications are invited for postdoctoral positions in human fat cell biology in the research groups of Prof Mikael Rydén and Assoc Prof Jurga Laurencikiene.

Research environment
The Lipid Laboratory at the Department of Medicine (H7), Karolinska Institutet focuses on studies of human adipose tissue and its pathophysiological role in promoting metabolic complications such as insulin resistance, dyslipidemia and hypertension. Our group is composed of about 15 scientists and support staff. We have a long track record in the field of translational medicine and several international collaborations resulting in important contributions to the research field [1-6]. Our work is based on examinations in large, carefully phenotyped prospective clinical cohorts and on well-established in vitro cell models using a number of standard and state-of-art methodologies (e.g. single cell RNA sequencing, multicolor flow cytometry, high throughput screens and cell phenotype analysis) as well as in-house developed techniques. We are now in an expansion phase due to our involvement in large collaborative efforts to determine the immunometabolic milieu of human adipose tissue and its role in adipocyte differentiation, adipose tissue morphology and the development of type 2 diabetes and cardiovascular disease.

Position
Up to two postdoctoral positions are now open for a highly motivated scientist with a strong background in molecular and cell biology.

Qualifications
To qualify, the applicant must hold a PhD in the field of molecular biology or biomedicine. A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances. the applicant can have a scheduled date for PhD-dissertation (in the mentioned subjects). In the later case, however, the employment can only be approved once the applicant has been awarded his/her doctoral degree.

Requirements
The applicant, ideally applying for his/her first or second postdoctoral position, should have experience from work in a translational research environment and excellent skills in standard molecular biology techniques as well as cell culture work including primary cell systems. Experience in handling analyses of large data sets, e.g. arrays and/or metabolomics data and/or experience in flow cytometry and advanced immunomicroscopy are an extra plus as well as knowledge of transcriptional regulation and practical experience from in vitro assays of cell function. A background in metabolism and/or immunology is meritorious but not an absolute requirement. As our research is performed with a translational perspective, our work implies handling of human samples and close collaboration with clinicians. We are looking for curious and ambitious persons that are eager to learn and that have the capacity to collaborate in teams.

What we can offer
We can offer an excellent environment for translational medicine and research at the forefront in the field of human metabolism. Our research groups work closely with Prof Peter Arner, a nestor in human adipose tissue field. Finally, our international collaborations enable short-term stays in other groups and we expect that generated findings are presented by the fellows at international meetings.

The position is for 2 years with the possibility for an additional 2 year-prolongation.
Duties are to be taken on as soon as possible.

Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted through the MyNetwork recruitment system.

References

1          Ryden, M. et al. Cell Metab 22, 408-417 (2015).

2          Gao, H. et al. Cell Metab (2014).

3          Spalding, K. L. et al. Nature 453, 783-787 (2008).

4          Ryden, M. et al. Cell reports 16, 2317-2326 (2016).

5          Acosta, J. R. et al. Diabetologia 59, 560-570 (2016).

6          Stenson, B. M. et al. J Biol Chem 286, 370-379 (2011).

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 2
Working hours 100%
City Huddinge
County Stockholms län
Country Sweden
Reference number 2-1049/2017
Contact
  • Professor/Senior physician Mikael Ryden, Email: Mikael.Ryden@ki.se
  • Senior researcher Jurga Laurencikiene, Email: Jurga.Laurencikiene@ki.se
Union representative
  • Yvonne Edlund OFR/ST , yvonne.edlund@ki.se
  • Mats Rudling, SACO, mats.rudling@ki.se
Published 28.Feb.2017
Last application date 28.Mar.2017 11:59 PM CET

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