Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 100 PhD students, 50 postdoctoral researchers and 26 professors. Key words are multidisciplinary, bridging, translational, national and international collaborations.

Division

MTC is offering a postdoctoral position in the field of RNA biology and genomics to work in the group of Dr. Vicent Pelechano. The group combines experimental and computational approaches to develop and apply novel genome-wide techniques to investigate eukaryotic transcription and gene expression (Pelechano et al.Nature 2013, Chabbert et al. Mol. Syst. Biol. 2015, Pelechano et al. Cell 2015). 

We are especially interested in understanding the regulatory mechanisms leading to the appearance of divergent gene expression programs in clonal cell population (http://pelechanolab.com/). Different cells in a population can present varying responses to the same stimulus. In some cases these differences are attributable to genetic mutations, such as the appearance of drug-resistant cells in bacterial and cancer populations. However, in other cases identical (clonal) cells can also display phenotypically heterogeneous responses. This non-genetic heterogeneity has a poorly understood origin but a significant impact on biology and human health.

Our lab is located in the newly established Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/) in the Karolinska Institute campus. SciLifeLab is equiped with state-of-the-art instrumentation and core facilities, and is home to the second largest sequencing cluster in Europe. SciLifeLab Stockholm is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology (KTH) and Stockholm University, and hosts research groups with diverse backgrounds and expertise, including basic biology, drug discovery, genomics, bioengineering, and translational medicine.

Duties

The available postdoctoral position concerns developing and applying novel genomic approaches to study non-genetic heterogeneity in clonal population of cells. The candidate will focus on the study of translation regulation and its contribution to cell-to-cell variability in S. cerevisiae, with a special focus on ribosome dynamics, tRNA biology and post-transcriptional regulation. In a second stage the candidate will expand his/her work to the study of human cells. The candidate will perform original research in genomics, and acquire the required experimental and computational skills necessary for the completion of the project.

The candidate will be responsible for developing and applying novel genome-wide approaches to answer biologically relevant questions. The successful candidate will take a strong lead in the experimental design, contribute to the analysis of his/her own data and collaborate with other team members.

The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate is also expected to participate in the general duties of the team and to effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment.

Entry requirements
A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances. Applicants to this position should have a PhD in genomics, RNA biology or molecular biology.

The candidate will preferentially have experience with post-transcriptional regulation and yeast genetics.   The successful applicant should have experience in RNA biology and molecular biology tools. A strong interest in interdisciplinary technology development, and novel and creative thinking abilities are essential.

Preferred experience also includes familiarity with bioinformatics and NGS analysis and proficiency interpreting genome-wide scale biological data. Experience in eukaryotic transcription, tRNA biology, ribosome profiling, RNA binding proteins, CLIP or RIP-Seq will be beneficial. Applicants wishing to integrate experimental and computational biology approaches are especially encouraged to apply.

Candidates interested in applying are encouraged to contact vicente.pelechano.garcia@ki.se for further information.

Application process
An employment application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
  5. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-1047/2017
Contact
  • Vicente Pelechano Garcia, Assistant Professor, vicente.pelechano.garcia@ki.se
Union representative
  • Nasrin Bavand-Chobot, OFR, Nasrin.Bavand@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
  • Daisy Hjelmqvist, SACO, daisy.hjelmqvist@ki.se
Published 22.Feb.2017
Last application date 02.Apr.2017 11:59 PM CET

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