Karolinska Institutet, Institutionen för fysiologi och farmakologi

At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

Applicants are invited for postdoctoral studies in the unit for receptor biology and signaling led by Dr. Gunnar Schulte (http://ki.se/en/fyfa/receptor-biology-and-signaling). Our overall research mission is to advance our understanding of the pharmacology of Class Frizzled receptors with special emphasis on ligand-receptor interaction, receptor complex stoichiometry and dynamics and mechanisms of signal initiation. We are investigating Frizzled pharmacology and molecular mechanisms of WNT/Frizzled signal transduction employing biochemical and cell biological approaches, cellular imaging technologies and molecular biology to promote the development of FZD-targeting drugs. The project is part of a collaboration with Prof Thomas Sakmar at the Rockefeller University.

Recent reviews from the group:

Frizzleds and WNT/β-catenin signaling--The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics. Schulte G. Eur J Pharmacol. 2015 Sep 15;763(Pt B):191-5. doi: 10.1016/j.ejphar.2015.05.031. PMID: 26003275

WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3. Dijksterhuis JP, Petersen J, Schulte G. Br J Pharmacol. 2014 Mar;171(5):1195-209. doi: 10.1111/bph.12364. PMID: 24032637

International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors. Schulte G. Pharmacol Rev. 2010 Dec;62(4):632-67. doi: 10.1124/pr.110.002931. PMID: 21079039

The successful applicant will study Class Frizzled receptor transduction mechanisms in cells and with purified proteins. The work will be centred on the mechanisms and dynamics of ligand-receptor interaction and receptor complex composition and dynamics using a combination of biochemical, cell biological, computational modelling and live-cell imaging approaches. The duties also provide opportunities to teach and supervise masters and PhD students. The postdoctoral fellow will take on lab managing responsibilities and collaborate closely with PhD students, other postdocs in the lab and a broad network of international collaborators. 

Entry requirements
Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

Other requirements
Experience with molecular biology (site-directed mutagenesis, cloning), GPCR pharmacology/biochemistry (ligand binding, receptor reconstitution, purification), protein biochemistry (immunoblotting, immunoprecipitation, protein purification) and microscopy (light and confocal microscopy, live cell imaging) is highly relevant. A background in (receptor) pharmacology is a plus.

The applicant must be ambitious and demonstrate a strong interest in GPCR pharmacology and protein biochemistry. An appropriate background to develop the proposed research area would be biochemistry, GPCR pharmacology and molecular biology. Positive attitude, high motivation and an intrinsic drive to push the borders of our current knowledge are a prerequisite for recruitment.

Fluency in written and spoken English is required. The successful candidate must have good communication skills, be capable of working in a structured and efficient way and have a willingness to work collaboratively. 

Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English:

  1. Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/meritportfolj )
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or studentorganisations, parental leave or similar circumstances
  5. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline).

The application is to be submitted on the MyNetwork recruitment system.

Type of employment Postdoktoralt stipendium
Contract type Full time
Reference number 2-949/2017
  • Gunnar Schulte, Associate Professor, Gunnar.Schulte@ki.se , +46-(0)8-524 87933
Union representative
  • Bo Rydqvist, SACO, 08-524 872 67, bo.rydqvist@ki.se
  • Henry Wölling, SEKO, 08-524 840 80, henry.wolling@ki.se
  • Magnus Anå, OFR, 08-524 864 37, magnus.ana@ki.se
Published 27.Feb.2017
Last application date 04.May.2017 11:59 PM CET

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