Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutets conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 100 PhD students, 50 postdoctoral researchers and 26 professors. Key words are multidisciplinary, bridging, translational, national and international collaborations.

Research Group

The research group of Dr Claudia Kotter seeks applications for a research assistant position in the field of RNA biology and genomics. The Kutter lab explores the molecular mechanism by which noncoding RNAs (i.e. long noncoding, transfer and small RNA) regulate genes and genome structure in somatic tissue and in the germline in mammals (Rudolph et al, Plops Genetics, 2016; Schmitt et al, Genome Research, 2014; Kotter et al, Plops Genetics, 2012; Kotter et al, Nature Genetics 2011). The research program for this position focuses on the regulation of noncoding RNAs during cell differentiation and disease progression, with a particular interest in the involvement of RNA binding proteins during transcript processing and how they synergize with other cofactors in mammalian systems by using diverse cell lines, mouse and human tissues as model system. The roles of noncoding RNAs are interrogated genome- and transcriptome-wide by employing a combination of next generation sequencing technologies and high-throughput genetic screening approaches, developing computational methods, along with additional biochemical, molecular and cell biological methods. The group uses an integrative and collaborative approach, and works closely with experimental and computational groups at the MTC, Science for Life Laboratory (SciLifeLab), and other local and international research groups. Additional professional training is available through summer schools and workshops. 

The laboratory is located in the newly established SciLifeLab on the Karolinska Institute campus in Stockholm. The SciLifeLab offers an attractive research environment, provides state-of-the-art instrumentation and core facilities, and is home to the second largest sequencing cluster in Europe. The SciLifeLab is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology (KTH), and Stockholm University. It hosts research groups with diverse backgrounds and expertise, creating a unique interface between basic biology, genomics, bioengineering, drug discovery, and translational medicine.

Duties

The successful applicant will apply and optimize novel transcriptome- and genome-wide approaches (such as RNA-sequencing and epigenome profiling techniques) to study the processing and regulation of noncoding RNAs in cultured cells, carry out validation experiments involving biochemical and molecular biological tools, and participate in the general duties of the team. The post holder will take a strong lead in the project management including data generation, analyses and interpretation, and collaborate with other team members. The ideal candidate is expected to report the scientific results by writing scientific reports, attending scientific meetings, and effectively communicate with peers. The ability to work in a highly interdisciplinary and international environment, and to engage in continuous professional development is a must.

Entry requirements

Applicants to this research assistant position are eligible to apply if they have obtained a Master’s degree. A strong background in genomics, molecular biology, genetics, and/or biochemistry is required. Proven experiences in pro- and eukaryotic RNA biology, gene regulation, tissue culture techniques and the CRISPR/Cas system are essential. Laboratory skills in protein expression (Baculovirus expression system) and purification (chromatography), as well as microscopy (phase contrast and fluorescent microscope) are important. Prior knowledge in bioinformatics and R programming for statistical computing and graphics is an asset. The ideal candidate should be collaborative, scientifically adventurous, and curiosity-driven. Research experience in different research laboratories abroad will be preferred. Any previous records of independent research on regulatory RNAs as well as productive interactions within a multi-disciplinary team environment (e.g. first- and/or co-author publications in high profile journals) are advantageous. All applicants should have good communication skills and be proficient in spoken and written English.

For more information on the work of the laboratory, please visit https://www.scilifelab.se/researchers/claudia-kutter/.

To make informal enquiries about the post, please contact Dr Claudia Kutter at claudia.kutter@ki.se

Application process
The application is to be submitted on the MyNetwork recruitment system.

At Karolinska Institutet a 6-month trial period is required for all permanent appointments.

Type of employment Visstidsanställning 3-6 månader
Contract type Full time
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-84/2017
Contact
  • Dr. Claudia Kutter, claudia.kutter@ki.se
Union representative
  • Nasrin Bavand-Chobot, OFR, Nasrin.Bavand@ki.se
  • Cecilia Björkdahl, SACO , 08-524 872 65
  • Henry Wölling, SEKO, 08-524 840 80, henry.wolling@ki.se
Published 10.Jan.2017
Last application date 12.Jan.2017 11:59 PM CET

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