The Department of Biosciences and Nutrition performs research and education in areas of medical science including bioorganic chemistry, molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition. The department offers an international study and working environment, including around 300 scientists, students, administrative and technical personnel.

Division
We are looking for a postdoctoral researcher to join the group of Professor Camilla Sjögren. The Sjögren team focuses on the role of DNA topology in chromosome dynamics and regulation using Saccharomyces cerevisiae as model organism. The team consists of two post doctors and two students of multiple nationalities, and is affiliated to two departments, Dept. of Bioscience and Nutrition (http://ki.se/en/bionut/startpage) and Dept. Cell and Molecular Biology (http://ki.se/en/cmb/startpage). The group is also associated to the Center for Innovative Medicine, CIMED (http://cimed.ki.se/).  The successful applicant will thus be part of multiple networks of international recognized scientists, and have access to up to date infrastructure and facilities.

Project
The project aims to disclose the role of DNA topology in transcription regulation using yeast model organisms. The project stems from published and ongoing research on the so called Smc5/6 complex, and for a detailed scientific background, we refer to the following articles:  Jeppsson, K., et al., Nat Rev Mol Cell Biol, 2014. 15: p. 601, Jeppsson et al., PLoS Genet., 2014; doi: 10.1371/journal.pgen.1004680, Kegel, A., et al., Nature, 2011, 471: p. 392, and Decorsiere, A., et al., Nature, 2016, 531: p. 386. In short, the project will determine if and how the level of DNA supercoiling actively controls gene expression. This includes construction of experimental models for analysis of transcription, DNA supercoiling, and chromatin composition in vivo. Depending on results and the interests of the successful applicant, in vitro biochemical analyses, and/or genetic screens to identify novel factors regulating the DNA topology/transcription interplay can also be performed.

Responsibilities
The successful applicant is expected to lead the project in collaboration with the PI and other members of the group. This includes planning and execution of experiments and evaluation of results. The postdoctoral researcher is also expected to deliver written and oral presentations of the project in English. He/she will also be actively involved in common duties in the laboratory, and supervise students when appropriate.  

The position is offered for 2 years initially, with a 6 months trial period.

Qualifiactions
Applicants are expected to be highly motivated, experienced and interactive researchers. They should also have a solid practical and theoretical knowledge of chromosome biology, and expertise in terms of genetic and molecular biological methods and techniques. This knowledge must be documented in the form of published scientific articles. Detailed knowledge in transcription regulation, DNA topology and/or the use of yeast models are considered as an asset.

Entry requirements
A person is eligible for a position as Postdoctoral Researcher if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The term can be extended under special circumstances.


Application process
An employment application must contain the following documents in English or Swedish:

  1. A complete curriculum vitae, including date of the thesis defense, title of the thesis, publication list, previous academic positions, academic title, current position, academic distinctions, and committee work.
  1. A letter with motivation for the application (maximum 1000 characters), and a summary of previous research experience with an account of the applicant’s own contribution (maximum 1000 characters).
  1. Contact details for a minimum of two persons of reference.

 The application is to be submitted through the MyNetwork recruitment system.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100 %
City Huddinge
County Stockholms län
Country Sweden
Reference number 2-18/2017
Contact
  • Camilla Sjögren, +46-8-524 877 84
  • Thomas Tinglöv, Head of Administration, +46-8-524 835 49
Union representative
  • Joseph Rafter, SACO, +46-8-524 83 545
  • Henry Wölling, SEKO, +46-8-524 840 80
  • Birgitta Lindqvist, OFR, +46-8-524 810 35
Published 17.Jan.2017
Last application date 30.Apr.2017 11:59 PM CET

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