At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. 37 research groups with various cancer research profiles are involved and we have around 120 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

Research group
The group of Pär Nordlund at the Department of Oncology and Pathology works on different aspects of molecular and cellular cancer research. Current work in the group is focused on understanding the efficacy and resistance mechanism for a range of different cancer drugs. The group also works on the generation of small molecule and protein based experimental therapeutics to probe novel mechanisms for cancer therapy. The Nordlund group has developed the Cellular Thermal Shift Assay (CETSA) – an innovative biophysical technique which is the first broadly applicable method for direct studies of drug target protein interactions in intact cells and tissues (Martinez Molina, Science 2013, 41:84). CETSA is also a novel, potentially transformative technique, for studies of the biochemistry of the cell at the proteome level, including protein-protein, protein-metabolite and protein-nucleic acid interactions (Martinez Molina & Nordlund, Ann Rev Pharm Toxic 201656:141, Savitski, Science 2014 346;6205). CETSA derived biomarkers have potentials to be valuable tools during cancer therapy. The group has two Thermo Fisher Q Exective Orbitrap instruments dedicated to the CETSA applications.

Duties
The successful applicant will work in a dynamic team, developing new implementations of proteome wide CETSA for applications in studies of mechanisms of drug action and resistance development and for discovery of diagnostic markers of therapeutic effect. The applicant will also help with MS training and supervision within the group. External collaboration with other research groups, including pharmaceutical companies, will be important in the project.

Qualifications
The successful candidate should have a strong background in mass-spectrometry based proteomics working with mammalian cell systems and good knowledge of molecular biology and protein chemistry. Experience with CETSA and previous industrial experience is a plus. We are looking for someone very enthusiastic about novel techniques and translational science.

The applicant is eligible for a position as Senior scientist if he or she has obtained a PhD and have at least 2 years of postdoctoral experience. We expect the candidate to be able to work highly independent as well as having very good work ethics and collaboration skills. Proficiency in English (oral and written) is a requirement.

Application process

An application must contain the following documents in English:

  1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances

The application is to be submitted on the MyNetwork recruitment system.

This position is initially for two years, with a good chance of extension.

Type of employment Visstidsanställning längre än 6 månader
Contract type Full time
Number of positions 1
Working hours 100 %
City Solna
County Stockholms län
Country Sweden
Reference number 2-5261/2016
Contact
  • Pär Nordlund, +46 (0)8-524 800 00
Union representative
  • Andreas Lundqvist, SACO, 46 8 517 76884, andreas.lundqvist@ki.se;
  • Mimmi Shoshan, SACO, 46-8-5177 5460
  • Helen Eriksson, OFR, 46-8-517 76279
Published 21.Dec.2016
Last application date 11.Jan.2017 11:59 PM CET

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