The group of Pär Nordlund at the Department of Oncology and Pathology works on different aspects of molecular and cellular cancer research. Current work in the group is focused on understanding the efficacy and resistance mechanism for a range of different cancer drugs. The group also works on the generation of small molecule and protein based experimental therapeutics to probe novel mechanisms for cancer therapy. The Nordlund group has developed the Cellular Thermal Shift Assay (CETSA) – an innovative biophysical technique which is the first broadly applicable method for direct studies of drug target protein interactions in intact cells and tissues (Martinez Molina, Science 2013, 41:84). CETSA is also a novel, potentially transformative technique, for studies of the biochemistry of the cell at the proteome level, including protein-protein, protein-metabolite and protein-nucleic acid interactions (Martinez Molina & Nordlund, Ann Rev Pharm Toxic 201656:141, Savitski, Science 2014 346;6205). CETSA derived biomarkers have potentials to be valuable tools during cancer therapy. The group has two Thermo Fisher Q Exective Orbitrap instruments dedicated to the CETSA applications.
The successful applicant will work in a dynamic team, developing new implementations of proteome wide CETSA for applications in studies of mechanisms of drug action and resistance development and for discovery of diagnostic markers of therapeutic effect. The applicant will also help with MS training and supervision within the group. External collaboration with other research groups, including pharmaceutical companies, will be important in the project.
The successful candidate should have a strong background in mass-spectrometry based proteomics working with mammalian cell systems and good knowledge of molecular biology and protein chemistry. Experience with CETSA and previous industrial experience is a plus. We are looking for someone very enthusiastic about novel techniques and translational science.
The applicant is eligible for a position as Senior scientist if he or she has obtained a PhD and have at least 2 years of postdoctoral experience. We expect the candidate to be able to work highly independent as well as having very good work ethics and collaboration skills. Proficiency in English (oral and written) is a requirement.
An application must contain the following documents in English:
The application is to be submitted on the MyNetwork recruitment system.
This position is initially for two years, with a good chance of extension.
|Type of employment||Visstidsanställning längre än 6 månader|
|Contract type||Full time|
|Number of positions||1|
|Working hours||100 %|
|Last application date||11.Jan.2017 11:59 PM CET|