Karolinska Institutet, Department of Oncology-Pathology, Group Ola Larsson

At the Department of Oncology-Pathology basic, translational and clinical research and educational activities related to cancer is carried out. Approximately 300 people from over 40 nations are currently working at the department. About 30 research groups with various cancer research profiles are involved and we have around 110 PhD students. The Department of Oncology-Pathology is responsible for undergraduate courses in Pathology, Oncology and Forensic Medicine for medical students, as well as for Tumor biology courses for biomedicine students and Pathology courses for opticians.

We are recruiting a doctoral (PhD) student. For more information regarding doctoral education at Karolinska Institutet (KI), see:

http://ki.se/en/phd/about-doctoral-education-at-ki

A doctoral student is admitted to third-cycle/doctoral education. A doctoral education consists of supervised research, combined with courses and other educational activities. An individual study plan is established for each doctoral student. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.

Research group
The Department of Oncology-Pathology is searching for a PhD student to work with Dr Ola Larsson to study the role of mRNA translation in macrophages during tumor development. More detail about the group can be found at http://ki.se/onkpat/ola-larssons-forskargrupp.

The doctoral student project and the duties of the doctoral student
One of the major challenges during anti-cancer therapy is to restrict invasiveness and metastatic dissemination. It is well established that Tumor Associated Macrophages (TAMs) are linked to tumor progression and poor survival. Therefore, shifting tumor-promoting macrophages towards a tumor-inhibitory phenotype is a therapeutic strategy. Altered selective mRNA translation has emerged as an important mode for regulation of gene expression during tumor progression. The goal of the project is to understand how mRNA translation controls macrophage phenotypes to see if this can be exploited for anti-cancer therapy. Although the project will include laboratory work, the project is largely based on statistical, bioinformatics and systems biology analyses of mRNA translation using data obtained both from cell models and patient materials. Therefore, students with undergraduate studies including bioinformatics/biostatistics with an interest to also perform wet lab studies; or students with undergraduate studies in e.g. molecular biology or biomedicine with a strong interest in statistics and analyses of large data sets are best suited for this educational project. The PhD student will analyze complex experimental data, interpret and present results and participate in the writing of scientific papers.

Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

  1. have been awarded a second-cycle/advanced/master qualification (i.e. master degree) or
  2. have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
  3. have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

  • Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

Skills
Applications are welcome from talented students with degrees in biostatistics, bioinformatics or equivalent; or students with degrees in molecular biology or biomedicine with a strong interest in statistics and analyses of large data sets. Documented post-graduation experience within the field of statistical and/or bioinformatics analysis of data from medical or biomedical research projects is preferable but not necessary. An understanding of mRNA translation and/or cancer biology is an advantage.

Personal qualities
We are seeking a highly motivated and creative person. The candidate should have good communication skills and ability to interact effectively and work productively in a team. Emphasis will be placed on personal suitability. Excellent ability to express themselves in speech and writing in English is a requirement.

Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.

Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions.

Your application should contain the following documents:

  • A personal letter and a curriculum vitae (Swedish or English)
  • Degree projects and previous publications, if any (Swedish or English)
  • Any other documentation showing the desirable skills and personal qualities described above (Swedish or English)
  • Documents certifying your general eligibility (see A above)
  • Documents certifying your specific eligibility (see B above)

Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

KI uses the following bases of assessment:

  • Documented subject knowledge of relevance to the area of research
  • Analytical skill
  • Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

All applicants will be informed when the recruitment is completed.

Type of employment Stanowisko PhD
Contract type Full time
Reference number 2-2471/2019
Contact
  • Ola Larsson, 08 524 812 28, ola.larsson@ki.se
Union representative
  • Andreas Lundqvist, SACO, 08 517 768 84
  • Helen Eriksson, OFR, 08 517 762 79
Published 21.May.2019
Last application date 11.Jun.2019 11:59 PM CET

Wróć do ofert pracy