Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism

Division
The Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, is located at the newly built and modern laboratory Biomedicum at Solna campus of Karolinska Institutet. The research at the Division of Molecular Metabolism aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease. The current research encompasses biochemical and genetic studies of patients with inherited diseases as well as basic scientific approaches to understand the regulation of mtDNA expression and other aspects of mitochondrial metabolism. Both patient material (tissues and cells) and genetically modified fruit flies (Drosophila melanogaster) and mice (Mus musculus) are used in these studies. The overall aim of the Division of Molecular Metabolism is to combine these different areas of research to get insights into disease pathophysiology and to develop novel treatments.

The Division of Molecular Metabolism offers an outstanding research environment and a close interaction between basic science and clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. The newly founded Max Planck Institute for Biology of Ageing - Karolinska Institutet Laboratory (MPI-KI laboratory) is also integrated into our laboratory. Excellent access to the most advanced resources in molecular and cell biology is available at the department and at the national core facilities at the Science for Life Laboratory.

We are currently looking for 1-2 highly motivated postdoctoral researchers, to join the research group of Nils-Göran Larsson.

Duties
Studies of the regulation of mitochondrial function with special focus on expression of the mitochondrial DNA (mtDNA). Mitochondria are essential for cell function and mitochondrial dysfunction has been implicated in a variety of hereditary diseases, normal ageing and age-related diseases and correct expression of mtDNA is essential for normal mitochondrial function. Using mouse and fly models, molecular biology and biochemistry, the group of Nils-Göran Larsson focuses on understanding basic molecular processes involved in regulating mitochondrial function as well as the impact of mitochondrial dysfunction on disease and ageing. In this project we aim at understanding fundamental mechanisms whereby the expression of the mitochondrial genome is regulated

Entry requirements
Applications are invited from enthusiastic and motivated individuals with a PhD in a relevant field. The applicant preferably has experience in cellular metabolism with a strong background in mitochondrial and molecular biology. Experience in biochemistry, bioenergetics and mouse or fruit fly genetics is of advantage. Experience in proteomics is desirable for one of the positions.
Good documentation skills as well as proficiency in both spoken and written English are required. The successful candidates should be able and willing to work in a team to pursue his/her research. Personal suitability is of great importance when evaluating the applicants

Application process
An employment application must contain the following documents in English or Swedish:

  1. Curriculum vitae (max 2 pages)
  2. List of publications
  3. Personal motivation letter, explaining your research interests (max 1 page)
  4. Contact information of at least two references

The application is to be submitted through the Varbi recruitment system.

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment Upon agreement
Salary Monthly
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-3179/2018
Contact
  • Camilla Koolmeister, head of division, Camilla.Koolmeister@ki.se
Union representative
  • Anne Edgren, OFR/S, P, O, 08-524 87570
  • Biborka Bereczky Veress, SACO, 46 70-173 85 75 , biborka.bveress@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
Published 04.Jun.2018
Last application date 25.Jun.2018 11:59 PM CET

Return to job vacancies