Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Vascular Biology

A doctoral position is an available doctoral education project to which a PhD student is to be recruited. This position is supported by Karolinska Institutet (KI) and the Swedish Research Council. An admission decision will not be taken until an individual study plan has been approved by the departmental admission board. The student is expected to start no later than June 1st 2018

After a candidate is selected, an admission process commences. The candidate is admitted as a student once an individual study plan for the doctoral education has been approved by the departmental admission board.  

For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral

The lab and technologies
The Jakobsson lab investigates processes of blood vessel formation and function in development and disease, with the aim to develop new therapies. The lab utilizes mouse models of human disease based on inducible genetic loss- and gain- of-function in combination with state-of-the-art confocal live imaging (multi-photon, in vivo and ex vivo). Please see our recent publications for examples, Jin et al, Nat. Cell Biol., 2017 and Wang et al, Development, 2017. We have access to drug screening platforms, proteomics and single cell RNA sequencing. The lab has an extensive international scientific network and is integrated in a highly interactive scientific environment with close contact with the clinic.

The project
The projects build on our previous findings on endothelial cell- signalling, behaviour and gene expression in vascular patterning and malformation, in the CNS. Here we will focus on mechanisms of arterio-venous establishment, aspects of the blood-brain-barrier/permeability as well as properties of the tumour vasculature in relation to metastases. The aim is to find novel ways of modulating angiogenesis and vessel function. Data acquisition will be facilitated by novel mouse models in combination with abovementioned technologies. Please visit the lab website (http://ki.se/en/mbb/lars-jakobsson-group) for an overview.

The Department and location
The Department of Medical Biochemistry and Biophysics at Karolinska Institutet conducts a broad spectrum of biomedical research and education. Presently our department consists of 12 research divisions with a total of approximately 450 employees. The PhD student will work in Dr. Lars Jakobsson’s group at the Division of Vascular Biology. In April 2018 the division is moving into a brand new research center within the campus in central Stockholm. This is one of Europe’s largest research buildings. Please see Biomedicum Stockholm

Who would we like to attract?
We are looking for a highly motivated, creative and interactive sharp mind with a passion for understanding biology in depth.

Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:

General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  1. has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education

State here any other formal entry requirements, beside the above, that an applicant must have to be considered for this project.

Skills and personal qualities
Specify skills and personal qualities necessary or desirable/advantageous for this project. Make it clear for the applicants what is necessary and what is only desirable.

Assessment criteria
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months.

Application process
An application must contain the following documents in Swedish or English:

  • A personal letter and curriculum vitae
  • A copy of degree certificates and associated certificates
  • A copy of degree projects and any previous publications

The application is to be submitted through the Varbi recruitment system.

Type of employment PhD placement
Contract type Full time
First day of employment upon agreement
Salary monthly
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number 2-6083/2017
  • Lars Jakobsson / Docent, 08-524 871 24
Union representative
  • Anne Edgren, OFR/S, P, O, 08-616 16 29
  • Biborka Bereczky Veress, SACO, 46 70-173 85 75 , biborka.bveress@ki.se
  • Henry Wölling, SEKO, henry.wolling@ki.se
Published 21.Dec.2017
Last application date 14.Jan.2018 11:59 PM CET

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