Karolinska Institutet,

At the Department of Physiology and Pharmacology we teach and conduct internationally acclaimed, high-quality research in Physiology, Pharmacology, Anesthesiology and Intensive care. We have around 400 employees, 30 research groups, and 90 doctoral students. Our research fields include cellular signaling, cardiovascular and respiratory systems, neuropsychopharmacology, neuroinflammation, pharmacogenetics, regenerative medicine, Renal System, anesthesiology and intensive care, muscle physiology and pain. Our collaboration with the clinics at Karolinska University Hospital provides unique opportunities for translational research within our subjects. More information about research at http://ki.se/fyfa_english

A doctoral position is an available doctoral education project to which a PhD student is to be recruited. After the selection process the process for admission to doctoral education will commence. An admission decision will not be taken until an individual study plan has been approved by the departmental admission board.

For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral

Research group
Research in the Ruas group is aimed at understanding the molecular mechanisms that mediate skeletal muscle adaptations to diverse challenges and their local and systemic consequences. We are particularly interested in understanding how exercised or sedentary skeletal muscle can crosstalk with other organs, and how it can affect individual health and disease. The common goal of the projects being developed in the laboratory is to better understand the signal transduction and gene regulatory pathways that control skeletal muscle function. With this knowledge, we aim at developing strategies that can be used as possible therapeutic avenues for the treatment of metabolic and degenerative diseases. The group offers a very dynamic international environment, with great opportunities for interdisciplinary collaboration. More information about the research group can be found at www.ki.se/research/jorgeruas.

The doctoral education project and the duties of the student
In this project the student will investigate the role of the tryptophan metabolite kynurenic acid (Kyna) and its receptor GPR35 in obesity and metabolic disease. The project includes an in vitro part using primary cell culture, recombinant viral vectors, gene expression and signal transduction analyses. In addition, the student will use and characterize tissue-specific knockout models to understand how GPR35 activation in different tissues contributes to the regulation of energy homeostasis. The project offers a comprehensive approach to research in muscle physiology and energy metabolism.

Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:

General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  1. has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education

Skills and personal qualities
The successful candidate is dedicated, able to take own initiatives, and to work in a team. A university education in medical sciences is expected and training in metabolism is considered a strength. Experience of experimental animal work is an advantage and students with prior experience in BSL2 cell culture will be given particular consideration, although this is not a requirement. Please specify previous laboratory experience in the application, and provide names and contact details for 2-3 reference persons. Applicants from all over the world are welcomed.

Assessment criteria
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months.

Application process
An application must contain the following documents in Swedish or English:

  • A personal letter and curriculum vitae
  • A copy of degree certificates and associated certificates
  • A copy of degree projects and any previous publications

The application is to be submitted through the MyNetwork recruitment system.

Type of employment PhD placement
Contract type Full time
First day of employment In agreement
Salary Monthly salary
Reference number 2-4591/2017
  • Jorge Ruas, research group leader, jorge.ruas@ki.se
Union representative
  • Bo Rydqvist, SACO, 08-524 872 67, bo.rydqvist@ki.se
  • Magnus Anå, OFR, 08-524 864 37, magnus.ana@ki.se
  • Henry Wölling, SEKO, 08-524 840 80, henry.wolling@ki.se
Published 11.Oct.2017
Last application date 31.Oct.2017 11:59 PM CET

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