Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism

The research at the Division of Molecular Metabolism aims at understanding the regulation of mitochondrial function and the role of mitochondrial dysfunction in disease. The laboratory offers an outstanding research environment and a close interaction between basic science and clinical science and diagnostics at the Centre for Inherited Metabolic Diseases (CMMS) at Karolinska University Hospital, Stockholm, Sweden. The Division of Molecular Metabolism also closely interacts with the newly founded Max Planck Institute for Biology of Ageing - Karolinska Institutet Laboratory (MPI-KI laboratory). The current research encompasses biochemical and genetic studies of patients with inherited metabolic diseases as well as basic scientific approaches to understand the regulation of mtDNA expression and other aspects of mitochondrial metabolism. Both patient material (tissues and cells) and genetically modified model organisms (fruit flies and mice) are used in these studies. The overall aim of the division is to combine these different areas of research to get insights into disease pathophysiology and to develop novel treatment strategies.

Research group
We use a range of model systems, including genetically modified fruit flies, to broaden our understanding of the molecular interactions that affect mitochondrial metabolism, both in health and disease. Our research aims at identifying the molecular consequences of metabolic derangements, by understanding how mitochondria function within the metabolic system. We also have a special focus on understanding the turnover of mitochondrial transcripts, and how changes in mitochondrial gene expression are regulated on a post-transcriptional level.

We are currently looking for at least one highly motivated postdoctoral researcher to join the research group of Anna Wredenberg and Christoph Freyer. For more information about the group, please visit. www.wredenberglab.com.

Entry requirements
Applications are invited from individuals of the highest calibre with a Ph.D. degree. A strong background in molecular biology and/or mouse or Drosophila genetics is required. Knowledge in mitochondrial biology is preferred, but not required. A working knowledge of the English language is required. Personal suitability is of great importance when evaluating the applicants.

A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc.

Application process
An employment application must contain the following documents in English:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
  • Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)
  • Contact information of two references, recommendation letters are also welcome

A brief letter of motivation (no more than one page)

The application is to be submitted on the MyNetwork recruitment system.

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment Upon agreement
Salary Monthly
Number of positions 1
Working hours 100%
City Solna
County Stockholms län
Country Sweden
Reference number 2-4498/2017
  • Anna Wredenberg / Senior researcher, +46 8 524 800 00
Union representative
  • Anne Edgren, OFR/S, P, O, 08-616 16 29
  • Biborka Bereczky Veress, SACO, 46 70-173 85 75
  • Henry Wölling, SEKO, 08-524 840 80,
Published 03.Oct.2017
Last application date 17.Nov.2017 11:59 PM CET

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