Karolinska Institutet, Institutionen för laboratoriemedicin

The Department of Laboratory Medicine consists of 9 divisions and is active in many areas of Laboratory Medicine. The department is involved in advanced basic scientific, clinical and epidemiological research. The department is one of the largest departments of education at Karolinska Institutet.

A doctoral position is an available doctoral education project to which a PhD student is to be recruited. After the selection process the process for admission to doctoral education will commence. An admission decision will not be taken until an individual study plan has been approved by the departmental admission board. For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral.

Research group
The Department of Laboratory of Medicine, located in Huddinge Campus, is one of the Karolinska Institutet’s largest departments with 9 research divisions including the Clinical Research Centre (CRC), where the project will be carried out. 350 people are employed at the department, half of which are PhD-students. The Centre provides the facilities needed for cell- and molecular biology research and the possibility to perform research in vivo. EL Andaloussi’s research group works primarily on : 1) extracellular vesicles, in particular exosomes, as therapeutic delivery vehicles and 2) splice switching oligonucleotides to modulate endogenous splicing mechanism of genes in a therapeutic context. The lab has different on-going projects related to the exosome field and oligonucleotides. The lab also has a wide number of close collaborations with labs both within and outside Karolinska Institutet. Most of the projects are focusing on development of therapeutic oligonucleotides and engineered exosomes for treatment of inflammation.

The doctoral education project and the duties of the student
The PhD-project will mostly revolve around the development of therapeutics against inflammation by targeting novel inflammatory targets with bioengineered extracellular vesicles and assess their safety in vivo. Most of the research will be conducted utilizing cell lines and animal models. The first part of the work will involve engineering of therapeutically active exosomes with proteins. Second part will involve testing these exosomes in normal and diseased mice.

A PhD-thesis at Karolinska Institutet encompasses 4 years full-time studies. Further information regarding the post graduate education can be found on http://www.ki.se/doctoral. Registration and the PhD-thesis will start in the fall of 2017. Prospective candidates should be highly motivated with the ability to work independently and as part of a team.

The applicants should have a solid background in basic biology or biotechnology. Practical lab experience is essential, especially in the following areas: expression and purification of recombinant proteins, fluorescent/confocal microscopy (ICC and IHC), protein analysis (Western blot, ELISA and IP), and cell culture work. It is crucial with previous experience from extensive work with mice. If the applicants is acquainted with the exosome field this would be considered as a merit. In addition, excellent proficiency in both spoken and written English is highly desired. We are looking for an energetic and passionate person who fits in, and actively contributes to our team.

Entry requirements for doctoral education at KI
To be eligible for doctoral education following requirements has to be met:
General entry requirements
A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:
1.has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
2.has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
3.has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Specific entry requirements
Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school:
Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information.
Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education

Assessment criteria
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject
The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months.

Application process
An application must contain the following documents in Swedish or English:
•A personal letter and curriculum vitae
•A copy of degree certificates and associated certificates
•A copy of degree projects and any previous publications

The application is to be submitted through the MyNetwork recruitment system.

Type of employment PhD placement
Contract type Part-time
First day of employment enligt överenskommelse
Salary fast
Number of positions 1
Working hours 50%
City Huddinge
County Stockholms län
Country Sweden
Reference number 2-4003/2017
Contact
  • Samir El-Andaloussi, Samir.El-Andaloussi@ki.se
Union representative
  • Carina Eklund, OFR, 08-585 826 65, carina.eklund@ki.se
  • Emilie Hultin, SACO, 08-585 811 68, emilie.hultin@ki.se
  • Karin Olsson, SEKO, karin.olsson@ki.se
Published 04.Sep.2017
Last application date 25.Sep.2017 11:59 PM CET

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