Karolinska Institutet, Department of Medical Biochemistry and Biophysics, division of Genome Biology

A doctoral position is an available doctoral education project to which a PhD student is to be recruited. After the selection process the process for admission to doctoral education will commence. An admission decision will not be taken until an individual study plan has been approved by the departmental admission board. For more information regarding doctoral (PhD) education, see: http://www.ki.se/doctoral

Professor Jiri Bartek, while maintaining his group at the Danish Cancer Society in Copenhagen, has started a new Genome Integrity team at Karolinska Institutet in Stockholm. The lab is hosted in the Science for Life Laboratory (SciLifeLab), a national center for molecular biosciences with focus on health and environmental research. At SciLifeLab the research group is surrounded by labs of other world leaders in cancer biology, and has access to national facilities for bioimaging, next generation sequencing, chemical biology, drug discovery and development, among others.

The group aims to discover new targets and markers for personalized cancer treatment and finding novel components or mechanisms of genome integrity maintenance.

The Genome Integrity group is formed by a young, dynamic and enthusiastic group of scientists of different backgrounds and knowledge and offers the perfect environment for a PhD candidate willing to learn and develop as an independent scientist. The group has obtained generous funding from the Swedish Research Council that secures its activities in the long term.

Division/Research group 
Research in the Bartek lab focuses on various mechanistic aspects of the DDR and DNA repair pathways. Of particular interest is discovery of targets and markers for personalized cancer treatment and finding novel components or mechanisms of genome integrity maintenance. Another of our long-term goals is to further unravel the principles of ribosome biogenesis surveillance.

For more information regarding Bartek´s research group at Karolinska Institutet, visit: http://ki.se/en/mbb/jiri-bartek-group

The doctoral education project and the duties of the student 
The student will be responsible for his / her own project and should be able to work well within a team of research group members and collaborators. The student should, with the guidance from the supervisor(s), be able to plan and perform experiments, analyze results, write scientific articles, and present results at scientific meetings.

The project lies within the subject areas of biochemistry, cancer biology and pharmacology and will be carried out within the context of a broader project focused on ribosomal and genotoxic stress responses in normal versus cancer cells. In this project, the student will investigate parameters of ribosome biogenesis and genotoxic stress under diverse biological conditions, aiming at better understanding and experimentally modulating these mechanisms as potential cancer therapeutic targets. The PhD student will work with biochemical and pharmacological characterization of pre-existing and newly identified tools and compounds that can impact ribosomal biogenesis and/or DNA damage response, and to test these in combinations with known standard therapies. This project is expected to provide important clues to the significance of ribosome biogenesis for cancer cell growth and survival. Furthermore, insights are expected into mechanisms of selected regulatory events in the nucleolus and phenotypic responses including potential impact on cell fate and genomic (in)stability upon their experimental alterations in diverse cellular models. The PhD student will practice a number of molecular and cellular techniques, including cell culture, RNAi, qPCR, immunofluorescence microscopy, live-cell imaging, high throughput screening. An important aspect of the project is the use and optimization of automated microscopy in combination with image analysis in order to obtain information from different cell types and parallel combinatorial treatments.

Entry requirements for doctoral education at KI 
To be eligible for doctoral education following requirements has to be met:

General entry requirements A person meets the general entry requirements for doctoral/third-cycle/PhD education (according to Higher Education Ordinance Chapt 7, section 39) if he/she:

  1. has been awarded advanced/second-cycle/master qualification (i.e. master degree) or
  2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle/master level, or
  3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad.

Specific entry requirements Proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school: Proficiency in the English language can be documented by an internationally recognized test such as TOEFL or IELTS, see web-link below for more information. Applicants who meet the general entry requirements (1 or 2 above) from a university in one of the Nordic countries fulfill the requirements in English.

For more information regarding general and specific entry requirements: http://ki.se/en/education/entry-requirements-eligibility-for-doctoral-education

Skills and personal qualities 
Successful candidates are expected to be highly talented, motivated and enthusiastic. Applicants should have innovative thinking and be eager to solve problems. We especially put an emphasis on motivation and interest for research in cancer biology and pharmaceutical cell biology. A master degree in pharmaceutical science, molecular medicine, biomedicine, or equivalent is highly desirable. Since the study involves the characterization of small molecules (drug candidates) previous experience from work with small molecules is considered a merit.

Excellent communication skills and fluency in both written and spoken English is a request. The applicants should have strong organizational skills with the ability to work both in a group but also individually. Emphasis will be placed on personal suitability.

Assessment criteria 
A selection will be made among qualified applicants on the basis of the ability to benefit from doctoral education. Karolinska Institutet uses the following bases of assessment:  - Documented subject knowledge of relevance to the area of research  - Analytical skill  - Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

The qualifications of the applicants will be evaluated on an overall basis.

Terms and conditions
All doctoral students at KI receive financial support during their doctoral education and employment on a doctoral studentship is the most common sort of support. During the time between recruitment and admission a short-term employment can be offered for up to 6 months.

Application process 
An application must contain the following documents in Swedish or English:

  • A personal letter and curriculum vitae
  • A copy of degree certificates and associated certificates
  • A copy of degree projects and any previous publications

The application is to be submitted through the MyNetwork recruitment system.

Type of employment PhD placement
Contract type Full time
Reference number 2-2564/2017
  • Per Moberg, Head of Division, +46 (0)8 524 812 66
Union representative
  • Anne Edgren, OFR/S, P, O, +46 (0)8-616 16 29
  • Biborka Bereczky Veress, SACO, +46 (0)70-173 85 75
  • Henry Wölling, SEKO, +46 (0)8-524 840 80
Published 19.May.2017
Last application date 09.Jun.2017 11:59 PM CET

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