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Karolinska Institutet, Institutionen för neurobiologi, vårdvetenskap och samhälle

The Department of Neurobiology Care Sciences and Society comprises 11 divisions and has about 500 employees. The NVS-department is located at KI Campus-Huddinge. The Department is responsible for education at basic and advanced levels, research education and clinical and experimental research within the different areas represented by the divisions.

Division and Research Constellation
At the division of clinical geriatrics, we conduct research and training, including medical candidates. The research is multi-faceted and is in close collaboration with institutions and clinics worldwide. We have some of our research focuses on neurodegenerative diseases, including Alzheimer 's disease (AD) and Parkinson's disease. The research is clinically oriented with an emphasis on diagnosis and treatment. The focus is on research using imaging methods, registry studies and treatment studies. We also have research on drugs and the elderly, clinical nutrition, stroke and stroke rehabilitation, and Parkinson's disease. The current postdoctoral studies will be done in a research constellation between Prof Maria Eriksdotter’s and Assoc. Prof Taher Darreh-Shori’s research groups.

Duties
We are looking for an enthusiastic and highly motivated scientist who is interested in working in a multi- disciplinary team at the forefront of translational Alzheimer's disease (AD) research. The project pursues a set of integrated aims spanning from basic research to development and implementation of new biomarkers and therapeutic agents. For instance, in two AD patients’ pilot studies we have used encapsulated nerve growth factor (NGF) releasing cells (EC Biodelivery), implanted stereotactically close to the cholinergic nuclei in the basal forebrain. The aim is revive the cholinergic network by providing trophic support and neuroprotection to the degenerating cholinergic neurons in patients with AD, as a disease-modifying/curative therapeutic strategy. We want now to optimize the conditions of the NGF-releasing encapsulated cells and identify the in vivo factors that may affect optimal activity of EC-NGF producing cells in the brain. We want also to understand whether the NGF released by EC cells affects the function of non-neuronal cholinoceptive cells, such as astrocytes and microglia since evidence suggest a two-way crosstalk between the cholinergic neurons and these cells in the context of the cholinergic anti-inflammatory pathway. The project will also consider the possible interaction between NGF-Cholinergic signaling loop and other neurotrophins, such BDNF and GDNF. The study will use various in vitro and ex vivo models and high-throughput quantitative and semi-quantitative assays’ portfolio available at our laboratory, such as 3D-cell cultures systems, various biological materials, such as human and animal tissues, as well as enzyme assays, ELISA, immunochemistry on tissue/cells, confocal microscopy.

The environment provides excellent post-doctoral training in an international working environment, with national and international collaborations, and possibilities to publish in high impact journals.

Entry requirements
Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.

The candidate should have a strong interest in neurodegenerative diseases, and must hold a non-Swedish PhD degree or a foreign qualification deemed equivalent to a doctoral degree within the area of biomedical research. The candidate should have documented experience in 3D cell culturing system, ex-vivo whole blood assay, immunochemistry and confocal microscopy. Previous experience in enzymology and pharmacology, and the related quantitative methods for enzyme activity measurements and protein quantification such as ELISA and western-blotting, and certain other ligand-protein binding assays such as Proximity Scintillation assay, Isothermal Titration Calorimetry, and/or Thermoflour assays is highly desirable.

The successful candidate will also be expected to have established record of high-quality scientific research and publications, ability to work both independently and as a member of a collaborative, scientific team, excellent verbal and written English skills, and to write and apply for grants.

Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.

The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.

Application process
An application must contain the following documents in English:

  1. Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/meritportfolj )
  2. A complete list of publications
  3. A summary of current work (no more than one page)
  4. Verifications for crediting of illness, military service, work for labour unions or studentorganisations, parental leave or similar circumstances
  5. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline).

The application is to be submitted on the MyNetwork recruitment system.

Type of employment Postdoctoral scholarship
Contract type Full time
Reference number 2-945/2017
Contact
  • Taher Darreh-Shori, Senior researcher,, +46 (0) 8-585 836 12, Taher.Darreh-Shori@ki.se
  • Homira Behbahani, Associate Professor , +46 (0) 8-585 836 24, Homira.Behbahani@ki.se
  • Maria Eriksdotter, Professor, Head of Department,, Maria.Eriksdotter@ki.se
Union representative
  • Agneta Öhlen, SACO, 08-524 837 53, Agneta.Ohlen@ki.se
  • Carina Dahlin, OFR , 08-524 836 92,
  • Henry Wölling, SEKO, 08-524 840 80, henry.wolling@ki.se
Published 22.Feb.2017
Last application date 27.Mar.2017 11:59 PM CET

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